Time trends towards earlier puberty in boys and girls with type 1 diabetes: Insights from the German Diabetes Prospective Follow‐up (DPV) registry, 2000 to 2021

Aim To examine the time trends and factors associated with the onset of puberty in children with type 1 diabetes (T1D) using data from the German Diabetes Prospective Follow‐up (Diabetes‐Patienten‐Verlaufsdokumentation [DPV]) registry. Methods A total of 13 127 children with T1D, aged 6 to 18 years,...

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Published in:Diabetes, obesity & metabolism obesity & metabolism, 2024-01, Vol.26 (1), p.293-300
Main Authors: Gohlke, Bettina, Reschke, Felix, Lanzinger, Stefanie, Boettcher, Claudia, Gemulla, Gitta, Thiele‐Schmitz, Susanne, Dunstheimer, Désirée, Boom, Louise, Woelfle, Joachim, Holl, Reinhard W.
Format: Article
Language:English
Subjects:
body composition
Body mass index
Children
Children & youth
clinical physiology
cohort study
Diabetes
Diabetes mellitus (insulin dependent)
Girls
Hemoglobin
Puberty
Trends
type 1 diabetes
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Summary:Aim To examine the time trends and factors associated with the onset of puberty in children with type 1 diabetes (T1D) using data from the German Diabetes Prospective Follow‐up (Diabetes‐Patienten‐Verlaufsdokumentation [DPV]) registry. Methods A total of 13 127 children with T1D, aged 6 to 18 years, were included in the analysis. Regression analysis was performed to investigate the relationship between diabetes duration, body mass index (BMI) standard deviation score (SDS), glycated haemoglobin (HbA1c) level, migration background, and the onset of puberty, stratified by sex. Results Our findings revealed a significant trend towards earlier puberty in both girls and boys with T1D over the observed period (2000 to 2021). Puberty onset in girls (thelarche Tanner stage B2) decreased from 11.48 (11.35‐11.65) years in 2000 to 10.93 (10.79‐11.08) years in 2021 and gonadarche (Tanner stage G2/testicular volume >3 mL) decreased from 12.62 (12.42‐12.82) years in 2000 to 11.98 (11.79‐12.16) years in 2021 in boys (both P 
ISSN:1462-8902
1463-1326
DOI:10.1111/dom.15315