Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis

Background Inflammation has been associated with tumor development and circulating inflammatory biomarkers have been proposed as possible predictors of recurrence of several solid tumors. However, the role of inflammation markers in differentiated thyroid carcinoma (DTC) is still uncertain. Objectiv...

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Bibliographic Details
Published in:Reviews in endocrine & metabolic disorders 2023-12, Vol.24 (6), p.1205-1216
Main Authors: Russo, Elena, Guizzardi, Mathilda, Canali, Luca, Gaino, Francesca, Costantino, Andrea, Mazziotti, Gherardo, Lania, Andrea, Uccella, Silvia, Di Tommaso, Luca, Ferreli, Fabio, Malvezzi, Luca, Spriano, Giuseppe, Mercante, Giuseppe
Format: Article
Language:English
Subjects:
Analysis
Development and progression
Diabetes
Endocrinology
Humans
Inflammation
Internal Medicine
Leukocytes (neutrophilic)
Lymphocytes
Lymphocytes - pathology
Medical prognosis
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Meta-analysis
Middle Aged
Monocytes
Prognosis
Prospective Studies
Solid tumors
Thyroid cancer
Thyroid carcinoma
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - pathology
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Summary:Background Inflammation has been associated with tumor development and circulating inflammatory biomarkers have been proposed as possible predictors of recurrence of several solid tumors. However, the role of inflammation markers in differentiated thyroid carcinoma (DTC) is still uncertain. Objective This meta-analysis aimed to assess the prognostic value of neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in patients with DTC. Methods Studies investigating the association between survival and preoperative circulating inflammatory markers in DTC patients were included. The primary outcome was disease-free survival (DFS). Cumulative logarithms of the hazard ratio (log-HRs) with 95% CI were calculated through the inverse variance method using a random-effects model. Results A total of 7599 patients with a mean age of 48.89 (95% CI 44.16–53.63) were included. The estimated pooled log-HRs for DFS were 0.07 for NLR (95% CI -0.12–0.26; p  = 0.43), -0.58 for LMR (95% CI -1.21–0.05; p  = 0.06), and 0.01 (95% CI 0–0.01; p  = 0.21) for PLR. Conclusions Our meta-analysis showed no association between NLR, PLR, LMR and DFS in DTC; however, more prospective data are needed to better define the association between inflammatory status and prognosis of DTC.
ISSN:1389-9155
1573-2606
DOI:10.1007/s11154-023-09845-x