Hepatic β-arrestins: potential roles in liver health and disease

Β-arrestins are intracellular scaffolding proteins that have multifaceted roles in different types of disorders. In this review article, we gave a summary about the discovery, characterization and classification of these proteins and their intracellular functions. Moreover, this review article focus...

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Bibliographic Details
Published in:Molecular biology reports 2023-12, Vol.50 (12), p.10399-10407
Main Authors: Eissa, Alzahraa Muhammad, Hassanin, Mohamed H., Ibrahim, Islam A. A. E. H.
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Arrestin
Arrestins - metabolism
beta-Arrestins - metabolism
Bile ducts
Biomedical and Life Sciences
Gallbladder
Hepatocytes
Histology
Humans
Intracellular
Kinases
Life Sciences
Lipids
Liver
Liver Diseases
Metabolism
Molecular biology
Morphology
Pharmacy
Physiology
Proteins
Proteins - metabolism
Review
Roles
Signal Transduction
Veins & arteries
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Description
Summary:Β-arrestins are intracellular scaffolding proteins that have multifaceted roles in different types of disorders. In this review article, we gave a summary about the discovery, characterization and classification of these proteins and their intracellular functions. Moreover, this review article focused on the hepatic expression of β-arrestins and their hepatocellular distribution and function in each liver cell type. Also, we showed that β-arrestins are key regulators of distinct types of hepatic disorders. On the other hand, we addressed some important points that have never been studied before regarding the role of β-arrestins in certain types of hepatic disorders which needs more research efforts to cover.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-023-08898-0