Testosterone restores TM3 and TM4 cell viability, reduces reactive oxygen species generation, and protects against atrazine‐induced stereological changes in rat testes

In this study, we performed the stereological examination of rat testes and evaluated the protective effect of testosterone against atrazine (ATZ) toxicity in TM3 Leydig and TM4 Sertoli cells. Testosterone intake in rats increased the volumetric density of the seminiferous tubules; tubular diameter;...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biochemical and molecular toxicology 2024-01, Vol.38 (1), p.e23562-n/a
Main Authors: Mgbudom‐Okah, Chidimma J., Abarikwu, Sunny O., Wegwu, Matthew O., Henkel, Ralf
Format: Article
Language:English
Subjects:
Animals
Atrazine
Atrazine - toxicity
Cell death
Cell lines
Cell Survival
Cell viability
Gametocytes
Herbicides
Leydig Cells
Male
Morphometry
Oxygen
Protected species
Rats
Reactive Oxygen Species
Sertoli cells
Sertoli Cells - metabolism
Spermatids
Spermatocytes
Spermatogenesis
Spermatogonia
Testes
testicular cell line
Testis - metabolism
Testosterone
Testosterone - pharmacology
Toxicity
Tubules
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, we performed the stereological examination of rat testes and evaluated the protective effect of testosterone against atrazine (ATZ) toxicity in TM3 Leydig and TM4 Sertoli cells. Testosterone intake in rats increased the volumetric density of the seminiferous tubules; tubular diameter; germinal epithelial height; number of spermatogonia, primary and secondary spermatocytes, round spermatids, Sertoli cells, and Leydig cells; and Johnsen scores compared with the values after ATZ treatment (p 
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.23562