Comparison of treatment outcomes between intermittent and daily regimens in non-cavitary nodular bronchiectatic-type Mycobacterium avium complex pulmonary disease in relation to sputum smear results: a retrospective cohort study

This study retrospectively analyzed the treatment outcomes of 110 patients with non-cavitary nodular bronchiectatic-type complex pulmonary disease who received intermittent or daily treatment with a three-drug oral antibiotic regimen (i.e., a macrolide, ethambutol, and rifampin) at a tertiary referr...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2023-11, Vol.67 (11), p.e0100323-e0100323
Main Authors: Jung, Junghee, Chong, Yong Pil, Lee, Hyun Joo, Shim, Tae Sun, Jo, Kyung-Wook
Format: Article
Language:English
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Summary:This study retrospectively analyzed the treatment outcomes of 110 patients with non-cavitary nodular bronchiectatic-type complex pulmonary disease who received intermittent or daily treatment with a three-drug oral antibiotic regimen (i.e., a macrolide, ethambutol, and rifampin) at a tertiary referral center in South Korea. Among these patients, 36 had sputum smear positivity. Of these 36 patients, intermittent treatment led to a lower culture conversion rate than daily treatment [50.0% (8/16) vs 85.0% (17/20), = 0.034].
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.01003-23