The interaction between alpha-synuclein and mitochondrial dysfunction in Parkinson's disease

Parkinson's disease (PD) is an aging-associated neurodegenerative disorder with the hallmark of abnormal aggregates of alpha-synuclein (α-syn) in Lewy bodies (LBs) and Lewy neurites (LNs). Currently, pathogenic α-syn and mitochondrial dysfunction have been considered as prominent roles that giv...

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Bibliographic Details
Published in:Biophysical chemistry 2023-12, Vol.303, p.107122-107122, Article 107122
Main Authors: Li, Hong-Yan, Liu, De-Shui, Zhang, Ying-Bo, Rong, Hua, Zhang, Xiao-Jie
Format: Article
Language:English
Subjects:
Alpha-synuclein
alpha-Synuclein - metabolism
Humans
Lewy Bodies - metabolism
Lewy Bodies - pathology
Mitochondria
Mitochondrial dysfunction
Mitochondrial homeostasis
Neurodegenerative Diseases - metabolism
Parkinson Disease - metabolism
Parkinson's disease
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Summary:Parkinson's disease (PD) is an aging-associated neurodegenerative disorder with the hallmark of abnormal aggregates of alpha-synuclein (α-syn) in Lewy bodies (LBs) and Lewy neurites (LNs). Currently, pathogenic α-syn and mitochondrial dysfunction have been considered as prominent roles that give impetus to the PD onset. This review describes the α-syn pathology and mitochondrial alterations in PD, and focuses on how α-syn interacts with multiple aspects of mitochondrial homeostasis in the pathogenesis of PD. [Display omitted] •The relationship between α-syn pathology and mitochondrial dysfunction is reciprocal in PD.•α-syn affects mitochondrial biogenesis, bioenergetics, dynamics, transport and quality control.•Mitochondrial dysfunction in turn leads to the α-syn pathology.•More researches are needed to investigate the interaction between α-syn pathology and mitochondrial dysfunction.
ISSN:0301-4622
1873-4200
DOI:10.1016/j.bpc.2023.107122