Assessing mechanical function of peristalsis with functional lumen imaging probe panometry: Contraction power and displaced volume

Background and Aims The distal contractile integral (DCI) quantifies the contractile vigor of primary peristalsis on high‐resolution manometry (HRM), whereas no such metric exists for secondary peristalsis on functional lumen imaging probe (FLIP) panometry. This study aimed to evaluate novel FLIP me...

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Bibliographic Details
Published in:Neurogastroenterology and motility 2023-12, Vol.35 (12), p.e14692-n/a
Main Authors: Halder, Sourav, Pandolfino, John E., Kahrilas, Peter J., Koop, Andree, Schauer, Jacob, Araujo, Isis K., Elisha, Guy, Kou, Wenjun, Patankar, Neelesh A., Carlson, Dustin A.
Format: Article
Language:English
Subjects:
Adult
Asymptomatic
Barium
Contractility
Contraction
dysphagia
endoscopy
Esophageal Motility Disorders - diagnosis
Esophagogastric Junction - diagnostic imaging
Esophagus
Esophagus - diagnostic imaging
Fluid flow
Humans
impedance
Manometry - methods
Mechanical properties
Motility
Muscle Contraction
Patients
Peristalsis
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Summary:Background and Aims The distal contractile integral (DCI) quantifies the contractile vigor of primary peristalsis on high‐resolution manometry (HRM), whereas no such metric exists for secondary peristalsis on functional lumen imaging probe (FLIP) panometry. This study aimed to evaluate novel FLIP metrics of contraction power and displaced volume in asymptomatic controls and a patient cohort. Methods Thirty‐five asymptomatic controls and adult patients (with normal esophagogastric junction outflow/opening and without spasm) who completed HRM and FLIP panometry were included. The patient group also completed timed barium esophagram (TBE). Contraction power (estimate of esophageal work over time) and displaced volume (estimate of contraction‐associated fluid flow) were computed from FLIP. HRM was analyzed per Chicago Classification v4.0. Key Results In controls, median (5th–95th percentile) contraction power was 27 mW (10–44) and displaced volume was 43 mL (17–66). 95 patients were included: 72% with normal motility on HRM, 17% with ineffective esophageal motility (IEM), and 12% with absent contractility. Among patients, DCI was significantly correlated with both contraction power (rho = 0.499) and displaced volume (rho = 0.342); p values 
ISSN:1350-1925
1365-2982
1365-2982
DOI:10.1111/nmo.14692