PEMMELA: a promising regimen at the expense of toxicity

[...]tumour evaluation methods in pleural mesothelioma are inherently difficult and response assessment can, therefore, be variable.7 The independent review in PEMMELA lowered the observed response rate to 45% (95% CI 29–62; 17 of 38 patients), alluding to the challenging nature of pleural mesotheli...

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Bibliographic Details
Published in:The lancet oncology 2023-11, Vol.24 (11), p.1161-1162
Main Authors: Smith, Samuel, Kao, Steven
Format: Article
Language:English
Subjects:
Cancer therapies
Chemotherapy
Clinical medicine
Immunotherapy
Lung cancer
Mesothelioma
Oncology
Response rates
Thyroid gland
Tomography
Toxicity
Tumors
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Summary:[...]tumour evaluation methods in pleural mesothelioma are inherently difficult and response assessment can, therefore, be variable.7 The independent review in PEMMELA lowered the observed response rate to 45% (95% CI 29–62; 17 of 38 patients), alluding to the challenging nature of pleural mesothelioma tumour assessment. The poor toxicity profile was further reflected in 76% of patients requiring a dose reduction or discontinuation of lenvatinib. [...]developing methods to better predict toxicity—and, thus, more specifically select patients—is required for the PEMMELA regimen to be adopted in clinical practice, particularly in the face of other immunotherapy options. [...]the implications of increasingly efficacious therapies poses a dilemma for the choice and sequencing of therapy.
ISSN:1470-2045
1474-5488
1474-5488
DOI:10.1016/S1470-2045(23)00512-0