Changes in retinal and choroidal optical coherence tomography angiography indices among young adults and children over 1 year

Optical coherence tomography angiography (OCT-A) indices are likely to change across time and optometrists should be aware of the variability expected during childhood development and in healthy adults. Cross-sectional studies have shown that OCT-A indices are associated with age in adults and child...

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Bibliographic Details
Published in:Clinical and experimental optometry 2024-08, Vol.107 (6), p.627-634
Main Authors: Lal, Barsha, Alonso-Caneiro, David, Read, Scott A, Carkeet, Andrew
Format: Article
Language:English
Subjects:
Adolescent
Adult
Angiography
Child
Children
Choroid - blood supply
Choroid - diagnostic imaging
Cross-Sectional Studies
Female
Fluorescein Angiography - methods
Follow-Up Studies
Humans
Longitudinal studies
Male
Medical imaging
Myopia
Perfusion
Prospective Studies
Retina
Retinal Vessels - diagnostic imaging
Tomography
Tomography, Optical Coherence - methods
Young Adult
Young adults
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Summary:Optical coherence tomography angiography (OCT-A) indices are likely to change across time and optometrists should be aware of the variability expected during childhood development and in healthy adults. Cross-sectional studies have shown that OCT-A indices are associated with age in adults and children. The aim of this study is to investigate longitudinal changes in retinal and choroidal OCT-A indices over 1 year among healthy children and young adults. This prospective longitudinal study captured macular OCT-A and OCT scans, and biometry measures at baseline and 1-year follow-up for 22 adults (18-30 years; -6.87 to +0.37 D) and 21 children (6-15 years; -5.75 to +0.25 D). Superficial and deep retinal layer, choriocapillaris and deep choroidal en face OCT-A images were analysed to extract magnification-corrected vascular indices in foveal, parafoveal and perifoveal regions. The retinal indices included foveal avascular zone metrics, perfusion, and vessel density. Flow deficit number, size, and density were extracted from choriocapillaris and perfusion density from deep choroid. Associations between annual changes in the OCT-A indices and axial length and baseline refraction were also studied. Among children, significant reductions were noted only in parafoveal superficial retinal and foveal and perifoveal deep retinal layer indices over 1 year (  
ISSN:0816-4622
1444-0938
1444-0938
DOI:10.1080/08164622.2023.2259907