Grafted Sertoli cells prevent neuronal cell death and memory loss induced by seizures

Epilepsy significantly reduces the patient’s quality of life, and we still need to develop new therapeutic approaches to control it. Transplantation of cells such as Sertoli cells (SCs), having a potent ability to release a variety of growth and immunoprotective substances, have made them a potentia...

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Published in:Metabolic brain disease 2023-12, Vol.38 (8), p.2735-2750
Main Authors: Mehranpour, Maryam, Sani, Mojtaba, Beirami, Amirreza, Hasanzadeh, Maral, Taghizadeh, Mohammad, Banihashemi, Mobina, Moghaddam, Meysam Hassani, Fathi, Mobina, Vakili, Kimia, Yaghoobpoor, Shirin, Eskandari, Neda, Abdollahifar, Mohammad-Amin, Bayat, Amir‑Hossein, Aliaghaei, Abbas, Heidari, Mohammad Hossain
Format: Article
Language:English
Subjects:
Astrocytes
Biochemistry
Biomedical and Life Sciences
Biomedicine
Caspase-3
Cell death
Convulsions & seizures
Epilepsy
Gliosis
Grafting
Hippocampus
Inflammation
Metabolic Diseases
Neurological diseases
Neurology
Neurons
Neurosciences
Oncology
Original Article
Pyramidal cells
Quality of life
Seizures
Sertoli cells
Spatial distribution
Transplantation
Transplants & implants
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Summary:Epilepsy significantly reduces the patient’s quality of life, and we still need to develop new therapeutic approaches to control it. Transplantation of cells such as Sertoli cells (SCs), having a potent ability to release a variety of growth and immunoprotective substances, have made them a potential candidate to deal with neurological diseases like epilepsy. Hence, this study aims to evaluate whether SCs transplant effectively protects the hippocampus astrocytes and neurons to oppose seizure damage. For this purpose, the effects of bilateral intrahippocampal transplantation of SCs were investigated on the rats with the pentylenetetrazol (PTZ) induced seizure. After one-month, post-graft analysis was performed regarding behavior, immunohistopathology, and the distribution of the hippocampal cells. Our findings showed SCs transplantation reduced astrogliosis, astrocytes process length, the number of branches, and intersections distal to the soma of the hippocampus in the seizure group. In rats with grafted SCs, there was a drop in the hippocampal caspase-3 expression. Moreover, the SCs showed another protective impact, as shown by an improvement in pyramidal neurons’ number and spatial distribution. The findings suggested that SCs transplantation can potently modify astrocytes’ reactivation and inflammatory responses.
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-023-01309-0