Sirtuin6 and Lipoxin A4 levels are decreased in severe periodontitis

• Published in: Clinical oral investigations 2023-12, Vol.27 (12), p.7407-7415
• Main Authors: Cekici, Ali, Sahinkaya, Selin, Donmez, M. Fatih, Turkmen, Emrah, Balci, Nur, Toygar, Hilal
• Format: Article
• Language: English
• Subjects: Apoptosis; Dentistry; Energy metabolism; Enzyme-linked immunosorbent assay; Gum disease; Homeostasis; Hypoxia; Inflammation; Inflammatory diseases; Lipoxin A4; Medicine; Oxidative stress; Periodontitis; Plaque index; Saliva; Serum levels
• ISSN: 1436-3771; 1432-6981; 1436-3771
• DOI: 10.1007/s00784-023-05330-6

Objective Sirtuin6 plays an important role in the regulation of inflammation, homeostasis, and apoptosis, and it has anti-inflammatory effects on several diseases. Lipoxin A4 is a pro-resolving lipid mediator of inflammation and inhibits hypoxia-induced apoptosis and oxidative stress. Considering that Lipoxin A4 and Sirtuin6 have protective effects on inflammatory diseases, the aim of this study is to determine the possible roles of these molecules on periodontitis inflammation in saliva and serum and to reveal the relationship of these data with clinical periodontal parameters. Material and methods A total of 20 stage III/grade B periodontitis and 20 periodontally healthy subjects were included in this cross-sectional study (all never smokers and systemically healthy). Clinical periodontal parameters (plaque index, probing pocket depth, bleeding on probing, clinical attachment loss) were recorded. Saliva and serum levels of Sirtuin6 and Lipoxin A4 were analyzed by enzyme-linked immunosorbent assay. Results Serum Sirtuin6 and saliva Lipoxin A4 levels were significantly lower in the periodontitis group than the control group (respectively, p  = 0.0098, p  = 0.0008). There were negative correlations between all periodontal clinical parameters and saliva Lipoxin A4 level ( p