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Sirtuin6 and Lipoxin A4 levels are decreased in severe periodontitis
Objective Sirtuin6 plays an important role in the regulation of inflammation, homeostasis, and apoptosis, and it has anti-inflammatory effects on several diseases. Lipoxin A4 is a pro-resolving lipid mediator of inflammation and inhibits hypoxia-induced apoptosis and oxidative stress. Considering th...
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| Published in: | Clinical oral investigations 2023-12, Vol.27 (12), p.7407-7415 |
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| container_end_page | 7415 |
| container_issue | 12 |
| container_start_page | 7407 |
| container_title | Clinical oral investigations |
| container_volume | 27 |
| creator | Cekici, Ali Sahinkaya, Selin Donmez, M. Fatih Turkmen, Emrah Balci, Nur Toygar, Hilal |
| description | Objective
Sirtuin6 plays an important role in the regulation of inflammation, homeostasis, and apoptosis, and it has anti-inflammatory effects on several diseases. Lipoxin A4 is a pro-resolving lipid mediator of inflammation and inhibits hypoxia-induced apoptosis and oxidative stress. Considering that Lipoxin A4 and Sirtuin6 have protective effects on inflammatory diseases, the aim of this study is to determine the possible roles of these molecules on periodontitis inflammation in saliva and serum and to reveal the relationship of these data with clinical periodontal parameters.
Material and methods
A total of 20 stage III/grade B periodontitis and 20 periodontally healthy subjects were included in this cross-sectional study (all never smokers and systemically healthy). Clinical periodontal parameters (plaque index, probing pocket depth, bleeding on probing, clinical attachment loss) were recorded. Saliva and serum levels of Sirtuin6 and Lipoxin A4 were analyzed by enzyme-linked immunosorbent assay.
Results
Serum Sirtuin6 and saliva Lipoxin A4 levels were significantly lower in the periodontitis group than the control group (respectively,
p
= 0.0098,
p
= 0.0008). There were negative correlations between all periodontal clinical parameters and saliva Lipoxin A4 level (
p
|
| doi_str_mv | 10.1007/s00784-023-05330-6 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2878710744</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2878710744</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-683074fae875b7d6944bf0db7661e36f3c978be50ba78eda8bfad7191e8022093</originalsourceid><addsrcrecordid>eNp9kE1PxCAQhonRuLr6BzyYJl68VIdCgR4362eyiQf1TGiZGjbddoXW6L8X7foRD16AzDzzDnkIOaJwRgHkeYiH4ilkLIWcMUjFFtmjnImUSUm3f70nZD-EJQDlQrJdMmFS5ZRmao9c3DvfD64ViWltsnDr7tW1yYwnDb5gExLjMbFYeTQBbRJbIdZjbY3edbZre9e7cEB2atMEPNzcU_J4dfkwv0kXd9e389kirVgm-lQoBpLXBpXMS2lFwXlZgy2lEBSZqFlVSFViDqWRCq1RZW2spAVFBVkGBZuS0zF37bvnAUOvVy5U2DSmxW4IOlNSSRp38Iie_EGX3eDb-DudFQCc85gbqWykKt-F4LHWa-9Wxr9pCvrDsR4d6-hYfzrWIg4db6KHcoX2e-RLagTYCITYap_Q_-z-J_YdvSuFUQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2900444191</pqid></control><display><type>article</type><title>Sirtuin6 and Lipoxin A4 levels are decreased in severe periodontitis</title><source>Springer Nature</source><creator>Cekici, Ali ; Sahinkaya, Selin ; Donmez, M. Fatih ; Turkmen, Emrah ; Balci, Nur ; Toygar, Hilal</creator><creatorcontrib>Cekici, Ali ; Sahinkaya, Selin ; Donmez, M. Fatih ; Turkmen, Emrah ; Balci, Nur ; Toygar, Hilal</creatorcontrib><description>Objective
Sirtuin6 plays an important role in the regulation of inflammation, homeostasis, and apoptosis, and it has anti-inflammatory effects on several diseases. Lipoxin A4 is a pro-resolving lipid mediator of inflammation and inhibits hypoxia-induced apoptosis and oxidative stress. Considering that Lipoxin A4 and Sirtuin6 have protective effects on inflammatory diseases, the aim of this study is to determine the possible roles of these molecules on periodontitis inflammation in saliva and serum and to reveal the relationship of these data with clinical periodontal parameters.
Material and methods
A total of 20 stage III/grade B periodontitis and 20 periodontally healthy subjects were included in this cross-sectional study (all never smokers and systemically healthy). Clinical periodontal parameters (plaque index, probing pocket depth, bleeding on probing, clinical attachment loss) were recorded. Saliva and serum levels of Sirtuin6 and Lipoxin A4 were analyzed by enzyme-linked immunosorbent assay.
Results
Serum Sirtuin6 and saliva Lipoxin A4 levels were significantly lower in the periodontitis group than the control group (respectively,
p
= 0.0098,
p
= 0.0008). There were negative correlations between all periodontal clinical parameters and saliva Lipoxin A4 level (
p
< 0.05) and between probing pocket depth, clinical attachment loss, and serum and saliva Sirtuin6 levels (respectively,
r
= − 0.465 and
r
= − 0.473,
p
< 0.05).
Conclusions
Decreased levels of serum Sirtuin6 and saliva Lipoxin A4 in periodontitis patients and their correlation with clinical periodontal parameters suggest that serum Sirtuin6 and saliva Lipoxin A4 may be related with periodontal inflammation.
Clinical relevance
Scientific rationale for the study: Sirtuin6 is one of seven members of the family of NAD + dependent protein that played an important role in the regulation of inflammation, energy metabolism, homeostasis, and apoptosis. Sirtuin6 is associated with the pathogenesis of several diseases. Lipoxin A4 is a lipid mediator that inhibits hypoxia-induced apoptosis and oxidative stress, and it has an active role in the resolution of periodontal inflammation. No studies that investigated the potential role Sirtuin6 and its relationship with inflammation resolution and apoptosis mechanisms in severe periodontitis patients.
Principal findings: the serum Sirtuin6 and saliva Lipoxin A4 levels were significantly lower and negatively correlated with clinical periodontal parameters in the patients with periodontitis than the healthy controls.
Practical implications: this study shows that serum Sirtuin6 and saliva Lipoxin A4 may be candidate biomarkers related with periodontal inflammation and estimating to periodontal status.
Clinical trial registration
NCT05417061.</description><identifier>ISSN: 1436-3771</identifier><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-023-05330-6</identifier><identifier>PMID: 37851128</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Apoptosis ; Dentistry ; Energy metabolism ; Enzyme-linked immunosorbent assay ; Gum disease ; Homeostasis ; Hypoxia ; Inflammation ; Inflammatory diseases ; Lipoxin A4 ; Medicine ; Oxidative stress ; Periodontitis ; Plaque index ; Saliva ; Serum levels</subject><ispartof>Clinical oral investigations, 2023-12, Vol.27 (12), p.7407-7415</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-683074fae875b7d6944bf0db7661e36f3c978be50ba78eda8bfad7191e8022093</cites><orcidid>0000-0002-5243-0948 ; 0000-0001-5166-2109 ; 0000-0001-7986-7085 ; 0000-0001-7409-1484 ; 0000-0002-4720-7469 ; 0000-0002-0554-9567</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37851128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cekici, Ali</creatorcontrib><creatorcontrib>Sahinkaya, Selin</creatorcontrib><creatorcontrib>Donmez, M. Fatih</creatorcontrib><creatorcontrib>Turkmen, Emrah</creatorcontrib><creatorcontrib>Balci, Nur</creatorcontrib><creatorcontrib>Toygar, Hilal</creatorcontrib><title>Sirtuin6 and Lipoxin A4 levels are decreased in severe periodontitis</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Objective
Sirtuin6 plays an important role in the regulation of inflammation, homeostasis, and apoptosis, and it has anti-inflammatory effects on several diseases. Lipoxin A4 is a pro-resolving lipid mediator of inflammation and inhibits hypoxia-induced apoptosis and oxidative stress. Considering that Lipoxin A4 and Sirtuin6 have protective effects on inflammatory diseases, the aim of this study is to determine the possible roles of these molecules on periodontitis inflammation in saliva and serum and to reveal the relationship of these data with clinical periodontal parameters.
Material and methods
A total of 20 stage III/grade B periodontitis and 20 periodontally healthy subjects were included in this cross-sectional study (all never smokers and systemically healthy). Clinical periodontal parameters (plaque index, probing pocket depth, bleeding on probing, clinical attachment loss) were recorded. Saliva and serum levels of Sirtuin6 and Lipoxin A4 were analyzed by enzyme-linked immunosorbent assay.
Results
Serum Sirtuin6 and saliva Lipoxin A4 levels were significantly lower in the periodontitis group than the control group (respectively,
p
= 0.0098,
p
= 0.0008). There were negative correlations between all periodontal clinical parameters and saliva Lipoxin A4 level (
p
< 0.05) and between probing pocket depth, clinical attachment loss, and serum and saliva Sirtuin6 levels (respectively,
r
= − 0.465 and
r
= − 0.473,
p
< 0.05).
Conclusions
Decreased levels of serum Sirtuin6 and saliva Lipoxin A4 in periodontitis patients and their correlation with clinical periodontal parameters suggest that serum Sirtuin6 and saliva Lipoxin A4 may be related with periodontal inflammation.
Clinical relevance
Scientific rationale for the study: Sirtuin6 is one of seven members of the family of NAD + dependent protein that played an important role in the regulation of inflammation, energy metabolism, homeostasis, and apoptosis. Sirtuin6 is associated with the pathogenesis of several diseases. Lipoxin A4 is a lipid mediator that inhibits hypoxia-induced apoptosis and oxidative stress, and it has an active role in the resolution of periodontal inflammation. No studies that investigated the potential role Sirtuin6 and its relationship with inflammation resolution and apoptosis mechanisms in severe periodontitis patients.
Principal findings: the serum Sirtuin6 and saliva Lipoxin A4 levels were significantly lower and negatively correlated with clinical periodontal parameters in the patients with periodontitis than the healthy controls.
Practical implications: this study shows that serum Sirtuin6 and saliva Lipoxin A4 may be candidate biomarkers related with periodontal inflammation and estimating to periodontal status.
Clinical trial registration
NCT05417061.</description><subject>Apoptosis</subject><subject>Dentistry</subject><subject>Energy metabolism</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Gum disease</subject><subject>Homeostasis</subject><subject>Hypoxia</subject><subject>Inflammation</subject><subject>Inflammatory diseases</subject><subject>Lipoxin A4</subject><subject>Medicine</subject><subject>Oxidative stress</subject><subject>Periodontitis</subject><subject>Plaque index</subject><subject>Saliva</subject><subject>Serum levels</subject><issn>1436-3771</issn><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PxCAQhonRuLr6BzyYJl68VIdCgR4362eyiQf1TGiZGjbddoXW6L8X7foRD16AzDzzDnkIOaJwRgHkeYiH4ilkLIWcMUjFFtmjnImUSUm3f70nZD-EJQDlQrJdMmFS5ZRmao9c3DvfD64ViWltsnDr7tW1yYwnDb5gExLjMbFYeTQBbRJbIdZjbY3edbZre9e7cEB2atMEPNzcU_J4dfkwv0kXd9e389kirVgm-lQoBpLXBpXMS2lFwXlZgy2lEBSZqFlVSFViDqWRCq1RZW2spAVFBVkGBZuS0zF37bvnAUOvVy5U2DSmxW4IOlNSSRp38Iie_EGX3eDb-DudFQCc85gbqWykKt-F4LHWa-9Wxr9pCvrDsR4d6-hYfzrWIg4db6KHcoX2e-RLagTYCITYap_Q_-z-J_YdvSuFUQ</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Cekici, Ali</creator><creator>Sahinkaya, Selin</creator><creator>Donmez, M. Fatih</creator><creator>Turkmen, Emrah</creator><creator>Balci, Nur</creator><creator>Toygar, Hilal</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5243-0948</orcidid><orcidid>https://orcid.org/0000-0001-5166-2109</orcidid><orcidid>https://orcid.org/0000-0001-7986-7085</orcidid><orcidid>https://orcid.org/0000-0001-7409-1484</orcidid><orcidid>https://orcid.org/0000-0002-4720-7469</orcidid><orcidid>https://orcid.org/0000-0002-0554-9567</orcidid></search><sort><creationdate>20231201</creationdate><title>Sirtuin6 and Lipoxin A4 levels are decreased in severe periodontitis</title><author>Cekici, Ali ; Sahinkaya, Selin ; Donmez, M. Fatih ; Turkmen, Emrah ; Balci, Nur ; Toygar, Hilal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-683074fae875b7d6944bf0db7661e36f3c978be50ba78eda8bfad7191e8022093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Apoptosis</topic><topic>Dentistry</topic><topic>Energy metabolism</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Gum disease</topic><topic>Homeostasis</topic><topic>Hypoxia</topic><topic>Inflammation</topic><topic>Inflammatory diseases</topic><topic>Lipoxin A4</topic><topic>Medicine</topic><topic>Oxidative stress</topic><topic>Periodontitis</topic><topic>Plaque index</topic><topic>Saliva</topic><topic>Serum levels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cekici, Ali</creatorcontrib><creatorcontrib>Sahinkaya, Selin</creatorcontrib><creatorcontrib>Donmez, M. Fatih</creatorcontrib><creatorcontrib>Turkmen, Emrah</creatorcontrib><creatorcontrib>Balci, Nur</creatorcontrib><creatorcontrib>Toygar, Hilal</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cekici, Ali</au><au>Sahinkaya, Selin</au><au>Donmez, M. Fatih</au><au>Turkmen, Emrah</au><au>Balci, Nur</au><au>Toygar, Hilal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sirtuin6 and Lipoxin A4 levels are decreased in severe periodontitis</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2023-12-01</date><risdate>2023</risdate><volume>27</volume><issue>12</issue><spage>7407</spage><epage>7415</epage><pages>7407-7415</pages><issn>1436-3771</issn><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Objective
Sirtuin6 plays an important role in the regulation of inflammation, homeostasis, and apoptosis, and it has anti-inflammatory effects on several diseases. Lipoxin A4 is a pro-resolving lipid mediator of inflammation and inhibits hypoxia-induced apoptosis and oxidative stress. Considering that Lipoxin A4 and Sirtuin6 have protective effects on inflammatory diseases, the aim of this study is to determine the possible roles of these molecules on periodontitis inflammation in saliva and serum and to reveal the relationship of these data with clinical periodontal parameters.
Material and methods
A total of 20 stage III/grade B periodontitis and 20 periodontally healthy subjects were included in this cross-sectional study (all never smokers and systemically healthy). Clinical periodontal parameters (plaque index, probing pocket depth, bleeding on probing, clinical attachment loss) were recorded. Saliva and serum levels of Sirtuin6 and Lipoxin A4 were analyzed by enzyme-linked immunosorbent assay.
Results
Serum Sirtuin6 and saliva Lipoxin A4 levels were significantly lower in the periodontitis group than the control group (respectively,
p
= 0.0098,
p
= 0.0008). There were negative correlations between all periodontal clinical parameters and saliva Lipoxin A4 level (
p
< 0.05) and between probing pocket depth, clinical attachment loss, and serum and saliva Sirtuin6 levels (respectively,
r
= − 0.465 and
r
= − 0.473,
p
< 0.05).
Conclusions
Decreased levels of serum Sirtuin6 and saliva Lipoxin A4 in periodontitis patients and their correlation with clinical periodontal parameters suggest that serum Sirtuin6 and saliva Lipoxin A4 may be related with periodontal inflammation.
Clinical relevance
Scientific rationale for the study: Sirtuin6 is one of seven members of the family of NAD + dependent protein that played an important role in the regulation of inflammation, energy metabolism, homeostasis, and apoptosis. Sirtuin6 is associated with the pathogenesis of several diseases. Lipoxin A4 is a lipid mediator that inhibits hypoxia-induced apoptosis and oxidative stress, and it has an active role in the resolution of periodontal inflammation. No studies that investigated the potential role Sirtuin6 and its relationship with inflammation resolution and apoptosis mechanisms in severe periodontitis patients.
Principal findings: the serum Sirtuin6 and saliva Lipoxin A4 levels were significantly lower and negatively correlated with clinical periodontal parameters in the patients with periodontitis than the healthy controls.
Practical implications: this study shows that serum Sirtuin6 and saliva Lipoxin A4 may be candidate biomarkers related with periodontal inflammation and estimating to periodontal status.
Clinical trial registration
NCT05417061.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37851128</pmid><doi>10.1007/s00784-023-05330-6</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5243-0948</orcidid><orcidid>https://orcid.org/0000-0001-5166-2109</orcidid><orcidid>https://orcid.org/0000-0001-7986-7085</orcidid><orcidid>https://orcid.org/0000-0001-7409-1484</orcidid><orcidid>https://orcid.org/0000-0002-4720-7469</orcidid><orcidid>https://orcid.org/0000-0002-0554-9567</orcidid></addata></record> |
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| identifier | ISSN: 1436-3771 |
| ispartof | Clinical oral investigations, 2023-12, Vol.27 (12), p.7407-7415 |
| issn | 1436-3771 1432-6981 1436-3771 |
| language | eng |
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| source | Springer Nature |
| subjects | Apoptosis Dentistry Energy metabolism Enzyme-linked immunosorbent assay Gum disease Homeostasis Hypoxia Inflammation Inflammatory diseases Lipoxin A4 Medicine Oxidative stress Periodontitis Plaque index Saliva Serum levels |
| title | Sirtuin6 and Lipoxin A4 levels are decreased in severe periodontitis |
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