Chemical substances and their activities in sea cucumber Apostichopus japonicus: A review

Apostichopus japonicus, also known as Stichopus japonicus, with medicinal and food homologous figures, is a globally recognized precious ingredient with extremely high nutritional value. There is no relevant review available through literature search, so this article selects the research articles th...

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Bibliographic Details
Published in:Archiv der Pharmazie (Weinheim) 2024-01, Vol.357 (1), p.e2300427-n/a
Main Authors: Lu, Chang, Wang, Xueyu, Ma, Jiahui, Wang, Mengtong, Liu, Wei, Wang, Guangyue, Ding, Yuling, Lin, Zhe, Li, Yong
Format: Article
Language:English
Subjects:
Animals
Apostichopus japonicus
biological activity
chemistry
Food
Saponins
sea cucumber
Sea Cucumbers
Stichopus - chemistry
Stichopus - physiology
Stichopus japonicus
Structure-Activity Relationship
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Summary:Apostichopus japonicus, also known as Stichopus japonicus, with medicinal and food homologous figures, is a globally recognized precious ingredient with extremely high nutritional value. There is no relevant review available through literature search, so this article selects the research articles through the keywords “sea cucumber” and “Apostichopus japonicus (Stichopus japonicus)” in six professional databases, such as Wiley, PubMed, ScienceDirect, ACS, Springer, and Web of Science, from 2000 to the present, summarizing the extraction, isolation, and purification methods for the four major categories (polysaccharides, proteins and peptides, saponins, and other components) of the A. japonicus chemical substances and 10 effective biological activities of A. japonicus. Included are anticoagulation, anticancer/antitumor activities, hematopoiesis, regulation of gut microbiota, and immune regulatory activities that correspond to traditional efficacy. Literature support is provided for the development of medicines and functional foods and related aspects that play a leading role in future directions. This review summarizes the main chemical components and pharmacological activities of Apostichopus japonicus. The focus is on the extraction and separation methods of active ingredients, as well as on structural identification, digestion, and absorption. Details are provided on anticoagulation, anticancer/antitumor activities, hematopoiesis, regulation of gut microbiota, and immune regulatory activities.
ISSN:0365-6233
1521-4184
DOI:10.1002/ardp.202300427