Decreased sympathetic nerve activity in young hypertensive rats reared by normotensive mothers

Early postnatal development can be significantly compromised by changes in factors provided by the mother, leading to increased vulnerability to hypertension in her offspring. TGR(mRen-2)27 (TGR) mothers, characterised by an overactivated renin-angiotensin system, exhibit altered ion composition in...

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Published in:Life sciences (1973) 2023-11, Vol.333, p.122179-122179, Article 122179
Main Authors: Babarikova, Katarina, Svitok, Pavel, Kopkan, Libor, Zeman, Michal, Molcan, Lubos
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Language:English
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Aorta
Blood pressure
Cross-fostering
Heart rate variability
Hypertension
Sympathetic nerve activity
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container_title Life sciences (1973)
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creator Babarikova, Katarina
Svitok, Pavel
Kopkan, Libor
Zeman, Michal
Molcan, Lubos
description Early postnatal development can be significantly compromised by changes in factors provided by the mother, leading to increased vulnerability to hypertension in her offspring. TGR(mRen-2)27 (TGR) mothers, characterised by an overactivated renin-angiotensin system, exhibit altered ion composition in their breast milk. Therefore, we aimed to analyse the impact of cross-fostering on cardiovascular parameters in hypertensive TGR and normotensive Hannover Sprague-Dawley (HanSD) offspring. We measured cardiovascular parameters in 5- to 10-week-old male offspring by telemetry. The expression of proteins related to vascular function was assessed by western blotting in the aortic samples obtained from 6- to 12-week-old male offspring. Plasma renin activity and plasma angiotensin II (Ang II) levels were evaluated by radioimmunoassay (RIA). The development of hypertension was in TGR accompanied by increased low-to-high frequency ratio (LF/HF; a marker of sympathovagal balance; 0.51 ± 0.16 in week 10). Furthermore, TGR exhibited increased aortic expression of mineralocorticoid receptor (MR; p 
doi_str_mv 10.1016/j.lfs.2023.122179
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TGR(mRen-2)27 (TGR) mothers, characterised by an overactivated renin-angiotensin system, exhibit altered ion composition in their breast milk. Therefore, we aimed to analyse the impact of cross-fostering on cardiovascular parameters in hypertensive TGR and normotensive Hannover Sprague-Dawley (HanSD) offspring. We measured cardiovascular parameters in 5- to 10-week-old male offspring by telemetry. The expression of proteins related to vascular function was assessed by western blotting in the aortic samples obtained from 6- to 12-week-old male offspring. Plasma renin activity and plasma angiotensin II (Ang II) levels were evaluated by radioimmunoassay (RIA). The development of hypertension was in TGR accompanied by increased low-to-high frequency ratio (LF/HF; a marker of sympathovagal balance; 0.51 ± 0.16 in week 10). Furthermore, TGR exhibited increased aortic expression of mineralocorticoid receptor (MR; p &lt; 0.05) and transforming growth factor beta type 1 (TGF-β1; p = 0.002) compared to HanSD offspring. Fostering significantly decreased sympathovagal balance (0.23 ± 0.10 in week 10) and, transiently, plasma Ang II levels and MR expression in TGR offspring reared by HanSD mothers. These findings highlight the importance of understanding the complex interplay between early life experiences, maternal factors, and later cardiovascular function. 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Furthermore, TGR exhibited increased aortic expression of mineralocorticoid receptor (MR; p &lt; 0.05) and transforming growth factor beta type 1 (TGF-β1; p = 0.002) compared to HanSD offspring. Fostering significantly decreased sympathovagal balance (0.23 ± 0.10 in week 10) and, transiently, plasma Ang II levels and MR expression in TGR offspring reared by HanSD mothers. These findings highlight the importance of understanding the complex interplay between early life experiences, maternal factors, and later cardiovascular function. 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subjects Aorta
Blood pressure
Cross-fostering
Heart rate variability
Hypertension
Sympathetic nerve activity
title Decreased sympathetic nerve activity in young hypertensive rats reared by normotensive mothers
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