Research progress on the mechanism of Treponema pallidum breaking through placental barrier

Congenital syphilis, a significant cause of fetal mortality worldwide, is a congenital infectious disease instigated by the vertical transmission of Treponema pallidum during pregnancy. Clinical manifestations include preterm delivery, stillbirth, neonatal skin lesions, skeletal abnormalities, and c...

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Bibliographic Details
Published in:Microbial pathogenesis 2023-12, Vol.185, p.106392-106392, Article 106392
Main Authors: Li, Weiwei, Yuan, Wei, Huang, Shaobin, Zou, Lin, Zheng, Kang, Xie, Dongde
Format: Article
Language:English
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Summary:Congenital syphilis, a significant cause of fetal mortality worldwide, is a congenital infectious disease instigated by the vertical transmission of Treponema pallidum during pregnancy. Clinical manifestations include preterm delivery, stillbirth, neonatal skin lesions, skeletal abnormalities, and central nervous system aberrations. The ongoing increase in the incidence of congenital syphilis, coupled with complexities in diagnosis, necessitates a detailed understanding of its pathogenesis for the development of improved diagnostic approaches, and to interrupt the route of vertical transmission. Drawing from the broader body of research associated with vertical transmission pathogens, we aim to clarify the potential mechanisms by which Treponema pallidum breaches the placental barrier to infect the fetus.
ISSN:0882-4010
1096-1208
DOI:10.1016/j.micpath.2023.106392