Systemic inflammatory response markers for prediction of response to neoadjuvant chemotherapy in patients with advanced gastric cancer

Tumour development is greatly influenced by the systemic inflammatory response. Inflammatory factors, such as NLR, PLR, and LMR, mirror the balance between systemic inflammation and anti-tumour response. The current investigation examined the predictive and prognostic value of NLR, PLR, and LMR in a...

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Published in:Cytokine (Philadelphia, Pa.) Pa.), 2023-12, Vol.172, p.156389-156389, Article 156389
Main Authors: Skórzewska, Magdalena, Pikuła, Agnieszka, Gęca, Katarzyna, Mlak, Radosław, Rawicz-Pruszyński, Karol, Sędłak, Katarzyna, Paśnik, Iwona, Polkowski, Wojciech P.
Format: Article
Language:English
Subjects:
Gastric cancer
Humans
LMR
Lymphocytes - pathology
neoadjuvant chemotherapy
Neoadjuvant Therapy
Neutrophils - pathology
NLR
PLR
Prognosis
Retrospective Studies
Stomach Neoplasms - pathology
Systemic inflammatory response markers
Systemic Inflammatory Response Syndrome - pathology
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Summary:Tumour development is greatly influenced by the systemic inflammatory response. Inflammatory factors, such as NLR, PLR, and LMR, mirror the balance between systemic inflammation and anti-tumour response. The current investigation examined the predictive and prognostic value of NLR, PLR, and LMR in advanced GC patients. This study is a retrospective, observational analysis involving 105 GC patients treated with NAC. Thestudy population included patients who met the eligibility criteria.The relationship between NLR, PLR, LMR, and demographic and clinical variables was assessed using theΧ2test. Survival data were analysed by Kaplan-Meier curves. High NLR levels were associated with more advanced tumour stage.Higher risk of no tumour regression after NAC was observed if a high pretreatment level of NLR or PLR was found. All patients with an increase in NLR after NAC had a significantly higher risk of no tumor response.In groups high (no change), increase, decrease, and low (no change), NLR and PLR OS medians were: 33, 67, 78, and not reached–NR and 34, 29, 36, and NR, respectively. All patients had a significantly higher risk of death if NLR increased after NAC. An increase in post-NAC PLR level was associated with an increased risk of death only if the PLR baseline value was low. NLR and PLR are promising predictive and prognostic factors in advanced GC patients treated with NAC.
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2023.156389