Nonlinear Relationship Between Serum Total Cholesterol Levels and the Severity of Hypertriglyceridemic Acute Pancreatitis: A Cohort Study in China

Background The relationship between total cholesterol (TC) levels and the severity of hypertriglyceridemic acute pancreatitis (HTGAP) remains unclear. Aims The aim of this study was to investigate the relationship between the levels of TC at admission with the severity of HTGAP, in order to apply it...

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Bibliographic Details
Published in:Digestive diseases and sciences 2023-12, Vol.68 (12), p.4466-4473
Main Authors: Liu, Ziyu, Liu, Zongshi, Li, Qi, Li, Xiaocui, Hao, Lijie, Qiu, Guangwei, Zhai, Huihong
Format: Article
Language:English
Subjects:
Biochemistry
Body mass index
C-reactive protein
Cholesterol
Cohort analysis
Confounding (Statistics)
Diabetes
Gastroenterology
Hepatology
Hypertension
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Oncology
Original Article
Pancreatitis
Transplant Surgery
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Summary:Background The relationship between total cholesterol (TC) levels and the severity of hypertriglyceridemic acute pancreatitis (HTGAP) remains unclear. Aims The aim of this study was to investigate the relationship between the levels of TC at admission with the severity of HTGAP, in order to apply it as a reliable predictor at early stage in clinical practice. Methods We performed a cohort study including 249 patients with AHTGP between November 2012 and April 2022 in XuanWu Hospital. Fasting TC was assayed within 24 h of admission, age, gender, body mass index, hypertension, diabetes mellitus, drinking, smoking, neutrophil–lymphocyte ratio, C-reactive protein and glucose were recorded as confounding factors. To evaluate the relationship of TC and the severity of HTGAP, we used smooth curve fitting and a segmented regression model with adjustment of confounding factors to analyze the threshold effect between TC and SAP occurrence risk. Results 249 Patients were enrolled. The incidence of SAP was 25.3% (63/249). A nonlinear relationship between TC level and the severity of HTGAP. 6.09 mmol/L was the optimal TC value associated with the lowest risk of SAP occurrence. Moreover, TC level was negatively correlated with risk of severe HTGAP occurrence for TC  6.09 mmol/L in HTGAP patients (OR 1.14, 95% CI 1.04–1.26, P  = 0.006). Conclusions We found that serum TC level is nonlinearly associated with the severity of HTGAP, and it can be a reliable predictor for early intervention and intensive care.
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-023-08025-w