Traumatic brain injury research: homogenising heterogeneity

Measurement of intracranial pressure and brain oxygen tissue pressure (PbtO2) can help to identify a secondary injury after traumatic brain injury in a potentially reversible stage. [...]a dual-monitoring approach has been suggested as an important decision-making strategy during early critical care...

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Bibliographic Details
Published in:Lancet neurology 2023-11, Vol.22 (11), p.973-975
Main Authors: Rubiano, Andres M, Lee, Kiwon
Format: Article
Language:English
Subjects:
Artificial intelligence
Biomarkers
Brain Injuries
Brain Injuries, Traumatic - therapy
Clinical trials
Coma
Decision making
Decompression
Humans
Intracranial pressure
Medical imaging
Neuroimaging
Patients
Physiology
Probes
Sampling
Traumatic brain injury
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Summary:Measurement of intracranial pressure and brain oxygen tissue pressure (PbtO2) can help to identify a secondary injury after traumatic brain injury in a potentially reversible stage. [...]a dual-monitoring approach has been suggested as an important decision-making strategy during early critical care of these patients. For future studies in traumatic brain injury, selecting patients using biomarkers and neuroimaging, to identify specific subtypes of injuries,5 might result in a study cohort without this bias. Because of the possible sampling bias, results can be erroneously attributed to the phenomenon under study, rather than to the method of sampling.6 In some patients, aspects such as autoregulation status might be homogeneous, thereby decreasing bias when evaluating the effect of care strategies that comprise multiple monitoring methods. [...]the number of patients who underwent cranial decompression is not provided. Because monitoring probes were inserted in the most affected frontal area, it is not clear how Payen and colleagues dealt with the probes if decompression was done during the first 5–10 days of management.
ISSN:1474-4422
1474-4465
DOI:10.1016/S1474-4422(23)00325-3