Outcomes Following Recent and Distant Neoadjuvant Radiation in Rectal Cancer: An Institutional Retrospective Review and Analysis of NSQIP

Neoadjuvant chemoradiotherapy (nCRT) is the standard of care in locally advanced rectal cancer (LARC). However, radiation therapy is thought to increase operative difficulty due to induction of fibrosis. Total neoadjuvant therapy (TNT) protocols increase the time between completion of radiation and...

Full description

Saved in:
Bibliographic Details
Published in:Clinical colorectal cancer 2023-12, Vol.22 (4), p.474-484
Main Authors: Arndt, Kevin, Ore, Ana Sofia, Quinn, Jeanne, Fabrizio, Anne, Crowell, Kristen, Messaris, Evangelos, Cataldo, Thomas
Format: Article
Language:English
Subjects:
Chemoradiotherapy - methods
Complications
Humans
Intraoperative Complications - pathology
Margin status
Neoadjuvant Therapy - methods
Neoplasm Staging
Postoperative Complications - epidemiology
Postoperative Complications - etiology
Quality Improvement
Rectal Neoplasms - pathology
Rectal Neoplasms - radiotherapy
Retrospective Studies
Surgery
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neoadjuvant chemoradiotherapy (nCRT) is the standard of care in locally advanced rectal cancer (LARC). However, radiation therapy is thought to increase operative difficulty due to induction of fibrosis. Total neoadjuvant therapy (TNT) protocols increase the time between completion of radiation and surgical resection which may lead to increased operative difficulty and complications. A single institution retrospective review of patients ≥18 years with LARC undergoing nCRT from 2015 to 2022. Patients were dichotomized in 2 cohorts:
ISSN:1533-0028
1938-0674
DOI:10.1016/j.clcc.2023.07.006