ECG/echo indexes in the diagnostic approach to amyloid cardiomyopathy: A head-to-head comparison from the AC-TIVE study

•The discordance between ECG and echocardiogram mass is a red flag of amyloid cardiomyopathy and can be measured by numerous ECG/echo indexes•The best performing ECG/echo index among subjects with echocardiographic suspicion of amyloid cardiomyopathy was the ratio between the sum of all QRS voltages...

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Published in:European journal of internal medicine 2024-04, Vol.122, p.68-77
Main Authors: Pagura, Linda, Porcari, Aldostefano, Cameli, Matteo, Biagini, Elena, Canepa, Marco, Crotti, Lia, Imazio, Massimo, Forleo, Cinzia, Pavasini, Rita, Limongelli, Giuseppe, Perlini, Stefano, Metra, Marco, Boriani, Giuseppe, Emdin, Michele, Sinagra, Gianfranco, Merlo, Marco, Longo, Francesca, Rossi, Maddalena, Varrà, Guerino Giuseppe, Saro, Riccardo, Dore, Franca, Girardi, Francesca, Vergaro, Giuseppe, Musumeci, Beatrice, Autore, Camillo, Cappelli, Francesco, Perfetto, Federico, Olivotto, Iacopo, Favale, Stefano, Carella, Maria Cristina, Guaricci, Andrea Igoren, Ciccone, Marco Matteo, Di Bella, Gianluca, Tomasoni, Daniela, Rella, Valeria, Branzi, Giovanna, Badano, Luigi, Parati, Gianfranco, Palmiero, Giuseppe, Caiazza, Martina, Caponetti, Angelo Giuseppe, Saturi, Giulia, Labate, Marianna Eleonora, Andreis, Alessandro, Paneva, Elena, De Ferrari, Gaetano Maria, Di Ienno, Luca, De Carli, Giuseppe, Giacomin, Elisa, Arzilli, Chiara
Format: Article
Language:English
Subjects:
Amyloid cardiomyopathy
ECG/echo indexes
Echocardiography
Electrocardiogram
Left ventricular mass
Light chain amyloidosis
Red flags
Transthyretin amyloidosis
Voltages
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Summary:•The discordance between ECG and echocardiogram mass is a red flag of amyloid cardiomyopathy and can be measured by numerous ECG/echo indexes•The best performing ECG/echo index among subjects with echocardiographic suspicion of amyloid cardiomyopathy was the ratio between the sum of all QRS voltages and maximum left ventricle wall thickness
ISSN:0953-6205
1879-0828
DOI:10.1016/j.ejim.2023.09.026