Plasma GDNF levels in spinal dysraphism and its relation with neurological impairment in children: A point of care study

GDNF plays a crucial role in the stimulation of recovery, neuroplasticity and synaptic reorganization after spinal cord injury providing neuroprotection and neuroregeneration. Plasma GDNF levels are upregulated in cases of spina bifida owing to the intrauterine damage of the exposed spinal cord. Our...

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Bibliographic Details
Published in:Journal of pediatric urology 2024-02, Vol.20 (1), p.46.e1-46.e8
Main Authors: Joseph, Delona Treesa, Bajpai, Minu, Yadav, D.K., Sharma, Shilpa, Anand, Sachit, Khan, M.A.
Format: Article
Language:English
Subjects:
GDNF
Neurogenic bladder bowel
Spina bifida
Urodynamics in neurogenic bladder
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Summary:GDNF plays a crucial role in the stimulation of recovery, neuroplasticity and synaptic reorganization after spinal cord injury providing neuroprotection and neuroregeneration. Plasma GDNF levels are upregulated in cases of spina bifida owing to the intrauterine damage of the exposed spinal cord. Our aim was to compare the plasma GDNF levels in patients of spina bifida with non-spina bifida cases and assess the correlation with neurological impairment at one year of follow up. Single centre prospective analysis of cases of spina bifida from 2020 to 2022 at presentation and after one year of follow up post-surgery. Cases with hernia and hydrocele without any other disorders were recruited into the control group. Plasma GDNF levels were assessed with immunoassay kits and compared with neurological involvement. 85 cases were included in the study. GDNF levels were elevated in cases compared to controls (mean 6.62 vs 1.76) with significant p value (
ISSN:1477-5131
1873-4898
DOI:10.1016/j.jpurol.2023.09.019