Limosilactobacillus fermentum IKP 111 reduces pathogen load and improves immunity of broilers when challenged with Salmonella enteritidis

• Published in: Microbial pathogenesis 2023-12, Vol.185, p.106401-106401, Article 106401
• Main Authors: Khan, Imran, Nawaz, Muhammad, Anjum, Aftab Ahmad, Ahmed, Mansur-ud-Din, Tanvir, Rabia, Sarwar, Noreen, Ashraf, Muhammad Adnan, Mehmood, Adnan, Aqib, Muhammad
• Format: Article
• Language: English
• Subjects: Antimicrobial; Limosilactobacillus; Probiotics; Salmonella
• ISSN: 0882-4010; 1096-1208
• DOI: 10.1016/j.micpath.2023.106401

In this study, we checked the effectiveness of L. fermentum IKP 111 in treating S. enteritidis infection in an in vivo study. Its oral administration to broiler chicks significantly reduced the colonization of S. enteritidis in the gut and there was a lower bacterial count of S. enteritidis in the droppings after infection. The administration of the probiotic L. fermentum IKP 111 also led to increase in weight gain in the broiler chicks as well as their immunomodulation against avian influenza virus (AIV) and Newcastle disease virus (NDV) as compared to the chicks challenged only with S. enteritidis. Our study provides evidence that the probiotic strain L. fermentum IKP 111 could be an alternate for controlling S. enteritidis infection while enhancing the gut health as well as the immune response of broiler chickens against viral infections. •The multidrug resistant S. enteritidis is prevalent in the poultry industry.•L. fermentum IKP 111 reduces colonization of S. enteritidis and enhances weight gain in broilers.•L. fermentum IKP 111 is a viable alternative to classical probiotics with the ability of immunomodulation in broilers.