Anti-amyloid potential of some phytochemicals against Aβ-peptide and α-synuclein, tau, prion, and Huntingtin protein

• Published in: Drug discovery today 2023-12, Vol.28 (12), p.103802-103802, Article 103802
• Main Authors: Jerom, Jenat Pazheparambil, Madhukumar, Sooryalekshmi, Nair, Raveendran Harikumaran, Narayanan, Sunilkumar Puthenpurackal
• Format: Article
• Language: English
• Subjects: alpha-Synuclein - metabolism; Alzheimer Disease - drug therapy; Amyloid; Amyloid beta-Peptides - metabolism; Humans; Huntingtin Protein - therapeutic use; Parkinson Disease - metabolism; Peptides - therapeutic use; Phytochemicals - pharmacology; Phytochemicals - therapeutic use; Prions - metabolism; Prions - therapeutic use; tau Proteins - metabolism
• ISSN: 1359-6446; 1878-5832
• DOI: 10.1016/j.drudis.2023.103802

Some molecules self-assemble to create complex structures through molecular self-assembly. Hydrogel preparation, tissue repair, and therapeutic drug delivery are a few applications of molecular self-assembly. However, the self-assembly of amino acids, peptides, and proteins forms amyloid fibrils, resulting in various disorders, most notably neurodegenerative ailments. Examples include the self-assembly of phenylalanine, which causes phenylketonuria; Aβ, which causes Alzheimer's disease; the tau protein, which causes both Alzheimer's and Parkinson's diseases; and α-synuclein, which causes Parkinson's illness. This review provides information related to phytochemicals of great significance that can prevent the formation of, or destabilize, amino acid, peptide, and protein self-assemblies.