Ferroelectric transducer arrays for transdermal insulin delivery

The goal of this research was the development of a portable therapeutic device for the treatment of diabetes. A 3×3 cymbal array has been successfully tested in noninvasive insulin delivery experiments. The cymbal is a composite flextensional transducer constructed from a poled PZT ceramic and shape...

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Bibliographic Details
Published in:Journal of materials science 2006, Vol.41 (1), p.211-216
Main Authors: Snyder, Benjamin, Lee, Seungjun, Smith, Nadine Barrie, Newnham, Robert E
Format: Article
Language:English
Subjects:
Acoustic resonance
acoustics
Amplification
animal experimentation
Arrays
Beams (radiation)
ceramics
diabetes
Ferroelectricity
Flat panels
Insulin
Lead zirconate titanates
Materials science
Medical devices
Polyurethane resins
polyurethanes
Portable equipment
Rabbits
rats
research and development
Transducers
ultrasonics
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Summary:The goal of this research was the development of a portable therapeutic device for the treatment of diabetes. A 3×3 cymbal array has been successfully tested in noninvasive insulin delivery experiments. The cymbal is a composite flextensional transducer constructed from a poled PZT ceramic and shaped metal endcaps that amplify the transducer motions by two orders of magnitude. Nine cymbals are wired in parallel and potted in polyurethane to form the flat panel arrays. When driven near resonance (20 kHz), the array generated a low intensity acoustic beam of 100 mW/cm². Animal experiments on hyperglycemic rats and rabbits demonstrated the ultrasonic enhancement of transdermal insulin delivery.
ISSN:0022-2461
1573-4803
DOI:10.1007/s10853-006-6080-3