Arctium lappa L. root polysaccharides ameliorate CCl4-induced acute liver injury by suppressing oxidative stress, inflammation and apoptosis

In this study, water-soluble polysaccharides purified from burdock root were used to intervene in carbon tetrachloride (CCl 4 )-induced acute liver injury (ALI) of BRL3A hepatocytes and rats. Our results indicated that CCl 4 significantly inhibited hepatocyte viability and upregulated the expression...

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Published in:Natural product research 2024-11, Vol.38 (22), p.4028-4033
Main Authors: Xiang, Wen, Wei, Jiayi, Lv, Lifei, Yu, Xinghui, Xie, Yan, Zhang, Li, Lu, Naiyan, Jiang, Wentao
Format: Article
Language:English
Subjects:
acute liver injury
Apoptosis
Arctium lappa
Carbon tetrachloride
Damage
Hepatocytes
Histopathology
Inflammation
Liver
Oxidative stress
polysaccharide
Polysaccharides
Reactive oxygen species
Saccharides
Tumor necrosis factor-α
Water purification
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Summary:In this study, water-soluble polysaccharides purified from burdock root were used to intervene in carbon tetrachloride (CCl 4 )-induced acute liver injury (ALI) of BRL3A hepatocytes and rats. Our results indicated that CCl 4 significantly inhibited hepatocyte viability and upregulated the expression of reactive oxygen species (ROS), malondialdehyde (MDA), pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6), and the pro-apoptotic protein Bax. However, Arctium lappa L. root polysaccharides (ALP) could effectively ameliorate liver function and histopathology, oxidative stress, and inflammatory markers. In addition, ALP reduced the expression of apoptotic markers and promoted the proliferation of damaged hepatocytes. In conclusion, ALP possesses a hepatoprotective effect mediated by attenuating oxidative damage, inflammation and apoptosis in ALI.
ISSN:1478-6419
1478-6427
1478-6427
DOI:10.1080/14786419.2023.2272287