Recent trends and risk factors associated with Clostridioides difficile infections in hospitalized patients with inflammatory bowel disease

Summary Background Clostridioides difficile infections (CDIs) are common among patients with inflammatory bowel disease (IBD) and can mimic and exacerbate IBD flares, thus warranting appropriate testing during flares. Aims To examine recent trends in rates of CDI and associated risk factors in hospi...

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Published in:Alimentary pharmacology & therapeutics 2024-01, Vol.59 (1), p.89-99
Main Authors: Spartz, Ellen J., DeDecker, Lauren C., Fansiwala, Kush M., Noorian, Shaya, Roney, Andrew R., Hakimian, Shahrad, Sauk, Jenny S., Chen, Po‐Hung, Limketkai, Berkeley N.
Format: Article
Language:English
Subjects:
Clostridioides difficile
Comorbidity
Crohn's disease
Hospitalization
Infections
Inflammatory bowel disease
Inflammatory bowel diseases
Intestine
Mortality
Patients
Risk factors
Trends
Ulcerative colitis
Vigilance
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Summary:Summary Background Clostridioides difficile infections (CDIs) are common among patients with inflammatory bowel disease (IBD) and can mimic and exacerbate IBD flares, thus warranting appropriate testing during flares. Aims To examine recent trends in rates of CDI and associated risk factors in hospitalized IBD patients, which may better inform targeted interventions to mitigate the risk of infection. Methods This is a retrospective analysis using the Nationwide Readmissions Database from 2010 to 2020 of hospitalized individuals with Crohn's disease (CD) or ulcerative colitis (UC). Longitudinal changes in rates of CDI were evaluated using International Classification of Diseases codes. Multivariable logistic regression evaluated the association between patient‐ and hospital‐related factors and CDI. Results There were 2,521,935 individuals with IBD who were hospitalized at least once during the study period. Rates of CDI in IBD‐related hospitalizations increased from 2010 to 2015 (CD: 1.64%–3.32%, p 
ISSN:0269-2813
1365-2036
1365-2036
DOI:10.1111/apt.17777