Expression of placental growth factor, neuropilin-1, and neuropilin-2 in primary pterygium tissue

Purpose The aim of this study was to evaluate the expression of placental growth factor (PLGF), neuropilin-1 (NP-1), and neuropilin-2 (NP-2) molecules in primary pterygium tissue compared with normal conjunctival tissue. Methods The records of 42 patients who underwent excision surgery with autograf...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 2024-03, Vol.262 (3), p.957-965
Main Authors: Gundogan, Ali Osman, Oltulu, Refik, Belviranli, Selman, Oltulu, Pembe
Format: Article
Language:English
Subjects:
Autografts
Conjunctiva - abnormalities
Female
Growth factors
Humans
Inflammation
Inflammatory Disorders
Medicine
Medicine & Public Health
Neuropilin
Neuropilin-1
Neuropilin-2
Nevus
Ophthalmology
Placenta
Placenta Growth Factor
Pterygium - diagnosis
Pterygium - surgery
Retrospective Studies
Skin Neoplasms
Surgery
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Summary:Purpose The aim of this study was to evaluate the expression of placental growth factor (PLGF), neuropilin-1 (NP-1), and neuropilin-2 (NP-2) molecules in primary pterygium tissue compared with normal conjunctival tissue. Methods The records of 42 patients who underwent excision surgery with autografts for primary pterygium (pterygium group) and 20 patients who underwent conjunctival nevus excision surgery (control group) in the same period were reviewed retrospectively. The samples obtained from the pterygium tissues in the pterygium group and the clean conjunctival tissues adjacent to the nevus in the control group were collected from the archive. Immunohistochemical stains of the primary antibodies—1/100 diluted PLGF, NP-1, and NP-2 (Abcam Cambridge Science Park, UK)—were applied to all groups. Staining intensities and the percentage of positive cells in epithelial, endothelial, stromal, and inflammatory cells were analyzed by an experienced pathologist. Results The positivity rates of PLGF and NP-2 expression in epithelial, endothelial, stromal, and inflammatory cells were found to be higher in the pterygium group than in the control group (PLGF: p  
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-023-06280-1