Oral squamous cell carcinomas and oral potentially malignant disorders: A Latin American study

• Published in: Oral diseases 2024-07, Vol.30 (5), p.2965-2984
• Main Authors: Gilligan, Gerardo, Panico, René, Lazos, Jerónimo, Morelatto, Rosana, Belardinelli, Paola, Criscuolo, Maria Ines, Bolesina, Nicolas, Molina Ávila, Ignacio, Pimentel Solá, Juan Martin, Rivarola, Emilce, Morgante, Maria Jimena, Ingrassia Tonelli, Maria Eugenia, Gimenez, Javier, Doratti, Pablo, Werner, Laura Cecilia, Prado‐Ribeiro, Ana Carolina, Brandão, Thais Bianca, Vechiato‐Filho, Aljomar Jose, Cuzzullin, Maria Claudia, Saldivia‐Siracusa, Cristina, Lopes, Marcio Ajudarte, Agostini, Michelle, Romañach, Mario José, Abrahão, Aline Corrêa, Fonsêca, Thamyres Campos, Kaminagakura, Estela, Anbinder, Ana Lia, Santos Alves, Kamilla, Almeida Lança, Maria Leticia, Sacsaquispe‐Contreras, Sonia, Rodriguez Ibazetta, Karem, Gerber‐Mora, Roberto, Aranda Romo, Saray, Tejeda Nava, Francisco Javier, Cordero‐Torres, Karina, Moreno Silva, Ricardo, Gonzalez‐Arriagada, Wilfredo, Toro, Raiza, Silveira, Felipe Martins, Gonzalez, Natalia, Vargas, Pablo Agustin, Santos‐Silva, Alan Roger, Bologna‐Molina, Ronell, Villarroel‐Dorrego, Mariana, Martinez, Benjamin, Piemonte, Eduardo
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Alcohol Drinking - epidemiology; Carcinoma, Squamous Cell - epidemiology; Carcinoma, Squamous Cell - pathology; Epidemiology; Female; Humans; Latin America; Latin America - epidemiology; Leukokeratosis; leukoplakia; Leukoplakia, Oral - epidemiology; Leukoplakia, Oral - pathology; Lip; Male; Middle Aged; Mouth Neoplasms - epidemiology; Mouth Neoplasms - pathology; Oral cancer; Oral carcinoma; Oral diseases; oral potentially malignant disorders; Oral squamous cell carcinoma; Precancerous Conditions - epidemiology; Precancerous Conditions - pathology; Regional differences; Retrospective Studies; Risk Factors; Smoking - epidemiology; Squamous cell carcinoma
• ISSN: 1354-523X; 1601-0825; 1601-0825
• DOI: 10.1111/odi.14778

Objective To determine the frequency of oral squamous cell carcinoma (OSCC) associated or not with oral potentially malignant disorders (OPMD), and the epidemiological profile and traditional risk factors in Latin America. Methods A retrospective observational study was conducted in 17 Latin American centres. There were included cases of OSCC, analysing age, gender, OSCC and their association with previous OPMD. Clinicopathological variables were retrieved. The condition of sequential‐OSCC versus OSCC‐de novo (OSCC‐dn) was analysed concerning the aforementioned variables. Quantitative variables were analysed using Student's t‐test, and qualitative variables with chi‐square. Results In total, 2705 OSCC were included with a mean age of 62.8 years old. 55.8% were men. 53.75% of the patients were smokers and 38% were common drinkers. The lateral tongue border was the most affected site (24.65%). There were regional variations in OPMD, being leukoplakia the most frequent. Of the overall 2705 OSCC cases, 81.4% corresponded to OSCC‐dn, while s‐OSCC were 18.6%. Regarding lip vermillion SCC, 35.7% corresponded to de novo lip SCC and 64.3% were associated with previous OPMD. Conclusions In Latin America, OSCC‐dn seems to be more frequent with regional variations of some clinical and histopathological features. Further prospective studies are needed to analyse this phenomenon.