Micro-arheometer: High throughput system for measuring of viscoelastic properties of single biological cells

The micro-arheometer (micro-array of rheometers) is a multi-functional system on a chip. It is capable of cell manipulation and sorting utilizing dielectrophoresis, as well as measuring frequency-dependent viscoelastic cell properties by applying a known force with the desired frequency (piezoelectr...

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Bibliographic Details
Published in:Sensors and actuators. B, Chemical Chemical, 2006-10, Vol.118 (1), p.20-27
Main Authors: Krayer, Joel, Tatic-Lucic, Svetlana, Neti, Sudhakar
Format: Article
Language:English
Subjects:
Bio-MEMS array
Dielectrophoresis
Micro-rheology
Unimorph
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Summary:The micro-arheometer (micro-array of rheometers) is a multi-functional system on a chip. It is capable of cell manipulation and sorting utilizing dielectrophoresis, as well as measuring frequency-dependent viscoelastic cell properties by applying a known force with the desired frequency (piezoelectric actuation) and measuring displacement using a piezoresistive read-out. The micro-arheometer will accelerate biomedical research generating a larger statistical data set in a shorter amount of time by automating the process of micro-rheology on multiple cells at a time.
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2006.04.080