Chemical modification of chitosan for developing of new hemostatic materials: A review

Uncontrolled bleeding that occurs during surgery, trauma, and in combat conditions is critical and require immediate action. Chitosan is a polysaccharide, obtained from natural sources with unique biological properties. It is often used as basis for local hemostatic agents (LHA). We summarized the d...

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Bibliographic Details
Published in:International journal of biological macromolecules 2023-12, Vol.253 (Pt 8), p.127608, Article 127608
Main Authors: Lunkov, A.P., Zubareva, A.A., Varlamov, V.P., Nechaeva, A.M., Drozd, N.N.
Format: Article
Language:English
Subjects:
Chitosan
Chitosan - chemistry
Chitosan - pharmacology
Chitosan-based materials
Hemorrhage - drug therapy
Hemostasis
Hemostatic materials
Hemostatics - chemistry
Hemostatics - pharmacology
Humans
Polymers - pharmacology
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Summary:Uncontrolled bleeding that occurs during surgery, trauma, and in combat conditions is critical and require immediate action. Chitosan is a polysaccharide, obtained from natural sources with unique biological properties. It is often used as basis for local hemostatic agents (LHA). We summarized the data on hemostatic properties of chitosan, commercially available chitosan-based products with focus in the field of chemical modification of chitosan. Various approaches are used to enhance hemostatic activity of chitosan-based materials. The approach with chemical modification of chitosan allows changing the properties of the polymer in order to obtain an active macromolecule that contributes to hemostasis. Ongoing research on the mechanism of interaction with blood components in the case of different chitosan derivatives will make it possible to identify promising directions for chemical modification to obtain an effective LHA. [Display omitted] •Chitosan is a unique base for local hemostatic agents (LHA) due to its cationic nature and biocompatibility.•Chemical modification significantly improves hemostatic properties of chitosan.•Research on chitosan derivatives will make it possible to identify promising directions for chemical modification to obtain an effective LHA.
ISSN:0141-8130
1879-0003
1879-0003
DOI:10.1016/j.ijbiomac.2023.127608