Quality of life measures in children with Down syndrome with disorders of gut–brain interaction

Down syndrome (DS) is associated with multiple medical comorbidities. Perhaps related to such, caregivers of individuals with DS report lower quality of life (QoL) compared to individuals without DS. It has been shown that disorders of gut‐brain interaction (DGBI) such as functional constipation (FC...

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Bibliographic Details
Published in:American journal of medical genetics. Part C, Seminars in medical genetics Seminars in medical genetics, 2023-12, Vol.193 (4), p.e32071-n/a
Main Authors: Ciciora, Steven L., Manickam, Kandamurugu, Saps, Miguel
Format: Article
Language:English
Subjects:
abdominal pain
Brain
Brain Diseases
Child
Comorbidity
Constipation
Constipation - complications
Constipation - diagnosis
Cross-Sectional Studies
Digestive system
Disorders
Down syndrome
Down Syndrome - complications
Down's syndrome
Female
functional constipation
Gastrointestinal symptoms
Gastrointestinal tract
Humans
Irritable bowel syndrome
Irritable Bowel Syndrome - complications
Irritable Bowel Syndrome - diagnosis
Male
Quality of Life
Surveys and Questionnaires
Citations: Items that this one cites
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Summary:Down syndrome (DS) is associated with multiple medical comorbidities. Perhaps related to such, caregivers of individuals with DS report lower quality of life (QoL) compared to individuals without DS. It has been shown that disorders of gut‐brain interaction (DGBI) such as functional constipation (FC) and irritable bowel syndrome (IBS) are common in individuals with DS. We measured caregiver‐reported QoL in individuals with DS with a DGBI and compared them to individuals with DS without a DGBI via a cross‐sectional national survey. All measures of QoL were lower in those with DS who meet criteria for a DGBI compared to those with DS without a DGBI. Males and females with DS and at least one DGBI had similar QoL scores. While FC was the most common DGBI seen in individuals with DS, there was no difference in any aspect of QoL in subjects with FC when compared to individuals with other DGBIs. However, all measures of QoL were lower in those with IBS compared to individuals with other DGBIs. These findings suggest that management of gastrointestinal symptoms from DGBIs, particularly IBS, may serve as a target for increasing QoL in a notable subset of individuals with DS.
ISSN:1552-4868
1552-4876
1552-4876
DOI:10.1002/ajmg.c.32071