Ecotoxicity of naproxen and its phototransformation products

The occurrence of pharmaceuticals in the environment is of great concern and only few data are available about the adverse effects of such molecules and their derivatives on non-target aquatic organisms. This study was designed to assess the toxic potential of Naproxen, a nonsteroidal anti-inflammat...

Full description

Saved in:
Bibliographic Details
Published in:The Science of the total environment 2005-09, Vol.348 (1), p.93-101
Main Authors: Isidori, Marina, Lavorgna, Margherita, Nardelli, Angela, Parrella, Alfredo, Previtera, Lucio, Rubino, Maria
Format: Article
Language:English
Subjects:
Animal, plant and microbial ecology
Animals
Anostraca - drug effects
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - radiation effects
Anti-Inflammatory Agents, Non-Steroidal - toxicity
Applied ecology
Biological and medical sciences
Chlorophyta - drug effects
Chlorophyta - growth & development
Cladocera - drug effects
Cladocera - physiology
Ecotoxicology, biological effects of pollution
Fundamental and applied biological sciences. Psychology
General aspects
Genotoxicity
Lethal Dose 50
Mutagenesis
Naproxen
Naproxen - chemistry
Naproxen - radiation effects
Naproxen - toxicity
Photochemistry
Reproduction - drug effects
Rotifera
Rotifera - drug effects
Rotifera - physiology
Toxicity testing
Toxicity Tests, Acute
Toxicity Tests, Chronic
Water Pollutants, Chemical - radiation effects
Water Pollutants, Chemical - toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The occurrence of pharmaceuticals in the environment is of great concern and only few data are available about the adverse effects of such molecules and their derivatives on non-target aquatic organisms. This study was designed to assess the toxic potential of Naproxen, a nonsteroidal anti-inflammatory, Naproxen Na, its freely water soluble sodium salt and their photoproducts in the aquatic environment. Bioassays were performed on algae, rotifers and microcrustaceans to assess acute and chronic toxicity. Furthermore, possible genotoxic effects of photoderivatives were investigated using SOS chromotest and Ames fluctuation test. The results showed that photoproducts were more toxic than the parent compounds both for acute and chronic values, while genotoxic and mutagenic effects were not found. These findings suggested the opportunity to consider derivatives in ecotoxicology assessment of drugs.
ISSN:0048-9697
1879-1026
DOI:10.1016/j.scitotenv.2004.12.068