Protective effect of soy isolate protein against streptozotocin induced gestational diabetes mellitus via TLR4/MyD88/NF-κB signaling pathway

• Published in: Biomedicine & pharmacotherapy 2023-12, Vol.168, p.115688-115688, Article 115688
• Main Authors: Wang, Shuijing, Ma, Liangkun, Ji, Jing, Huo, Ruichao, Dong, Shan, Bai, Yunfeng, Hua, Linlin, Lei, Jiao, Tian, Sasa, Wang, Manning, Yu, Yan
• Format: Article
• Language: English
• Subjects: Antioxidant; Inflammation; Insulin; MRNA expression; Soy isolate protein
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2023.115688

Gestational diabetes mellitus (GDM) is a serious complication of pregnancy that is characterized by high blood sugar levels that occur due to insulin resistance and dysfunction in glucose metabolism during pregnancy. It usually develops in the second or third trimester of pregnancy and affects about 7 % of all pregnancies worldwide. In this experimental study, we scrutinized the GDM protective effect of soy isolate protein against streptozotocin (STZ) induced GDM in rats and explore the underlying mechanism. Sprague-Dawley (SD) rats were used in this experimental study. A 55 mg/kg intraperitoneal injection of streptozotocin (STZ) was administered to induce diabetes in female rats, followed by oral administration of soy isolate protein for 18 days. Body weight, glucose levels, and insulin were measured at different time intervals (0, 9, and 18 days). Lipid profiles, antioxidant levels, inflammatory cytokines, apoptosis parameters, and mRNA expression were also assessed. Pancreatic and liver tissues were collected for histopathological examination during the experimental study. Soy isolate protein significantly (P