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Prediagnostic serum concentrations of per‐ and polyfluoroalkyl substances and risk of papillary thyroid cancer in the Finnish Maternity Cohort
Human exposure to per‐ and polyfluoroalkyl substances (PFAS) occurs globally through contaminated food, dust, and drinking water. Studies of PFAS and thyroid cancer have been limited. We conducted a nested case‐control study of prediagnostic serum levels of 19 PFAS and papillary thyroid cancer (400...
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| Published in: | International journal of cancer 2024-03, Vol.154 (6), p.979-991 |
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| creator | Madrigal, Jessica M. Troisi, Rebecca Surcel, Heljä‐Marja Öhman, Hanna Kivelä, Juha Kiviranta, Hannu Rantakokko, Panu Koponen, Jani Medgyesi, Danielle N. Kitahara, Cari M. McGlynn, Katherine A. Sampson, Joshua Albert, Paul S. Ward, Mary H. Jones, Rena R. |
| description | Human exposure to per‐ and polyfluoroalkyl substances (PFAS) occurs globally through contaminated food, dust, and drinking water. Studies of PFAS and thyroid cancer have been limited. We conducted a nested case‐control study of prediagnostic serum levels of 19 PFAS and papillary thyroid cancer (400 cases, 400 controls) in the Finnish Maternity Cohort (pregnancies 1986‐2010; follow‐up through 2016), individually matched on sample year and age. We used conditional logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for log2 transformed and categorical exposures, overall and stratified by calendar period, birth cohort, and median age at diagnosis. We adjusted for other PFAS with Spearman correlation rho = 0.3‐0.6. Seven PFAS, including perfluoroctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), N‐ethyl‐perfluorooctane sulfonamidoacetic acid (EtFOSAA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluorohexane sulfonic acid (PFHxS) were detected in >50% of women. These PFAS were not associated with risk of thyroid cancer, except for PFHxS, which was inversely associated (OR log2 = 0.82, 95% CI: 0.70‐0.97). We observed suggestive but imprecise increased risks associated with PFOA, PFOS, and EtFOSAA for those diagnosed at ages |
| doi_str_mv | 10.1002/ijc.34776 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2884185172</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2884185172</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3536-dd51f1f38c1433c691373a9c0c4445e5b5d69de1b865a8c84bf0529f94594bcb3</originalsourceid><addsrcrecordid>eNp1kc1u1DAUhS0EotPCghdAltjAIq2vf-J4iUYUilqVBawjx3EYTzN2sB2h7HiEPmOfpO5MywKJ1ZXu_c7R0T0IvQFyCoTQM7c1p4xLWT9DKyBKVoSCeI5W5UYqCaw-QscpbQkBEIS_REdMKkKpFCt0-y3a3umfPqTsDE42zjtsgjfW56izCz7hMODJxrs_t1j7Hk9hXIZxDjHo8WYZcZq7lHURpP05unSzV-jJjaOOC86bJQbXY_MARex82Vh87rx3aYOvdLbRu7zgddiEmF-hF4Mek339OE_Qj_NP39dfqsvrzxfrj5eVYYLVVd8LGGBgjQHOmKkVMMm0MsRwzoUVnehr1VvomlroxjS8G4igalBcKN6Zjp2g9wffKYZfs0253blkbInsbZhTS5uGQyNA0oK--wfdhjn6kq6lCiRQqKUs1IcDZWJIKdqhnaLblQe0QNqHmtpSU7uvqbBvHx3nbmf7v-RTLwU4OwC_3WiX_zu1F1_XB8t7SzmfQQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2917121677</pqid></control><display><type>article</type><title>Prediagnostic serum concentrations of per‐ and polyfluoroalkyl substances and risk of papillary thyroid cancer in the Finnish Maternity Cohort</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Madrigal, Jessica M. ; Troisi, Rebecca ; Surcel, Heljä‐Marja ; Öhman, Hanna ; Kivelä, Juha ; Kiviranta, Hannu ; Rantakokko, Panu ; Koponen, Jani ; Medgyesi, Danielle N. ; Kitahara, Cari M. ; McGlynn, Katherine A. ; Sampson, Joshua ; Albert, Paul S. ; Ward, Mary H. ; Jones, Rena R.</creator><creatorcontrib>Madrigal, Jessica M. ; Troisi, Rebecca ; Surcel, Heljä‐Marja ; Öhman, Hanna ; Kivelä, Juha ; Kiviranta, Hannu ; Rantakokko, Panu ; Koponen, Jani ; Medgyesi, Danielle N. ; Kitahara, Cari M. ; McGlynn, Katherine A. ; Sampson, Joshua ; Albert, Paul S. ; Ward, Mary H. ; Jones, Rena R.</creatorcontrib><description>Human exposure to per‐ and polyfluoroalkyl substances (PFAS) occurs globally through contaminated food, dust, and drinking water. Studies of PFAS and thyroid cancer have been limited. We conducted a nested case‐control study of prediagnostic serum levels of 19 PFAS and papillary thyroid cancer (400 cases, 400 controls) in the Finnish Maternity Cohort (pregnancies 1986‐2010; follow‐up through 2016), individually matched on sample year and age. We used conditional logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for log2 transformed and categorical exposures, overall and stratified by calendar period, birth cohort, and median age at diagnosis. We adjusted for other PFAS with Spearman correlation rho = 0.3‐0.6. Seven PFAS, including perfluoroctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), N‐ethyl‐perfluorooctane sulfonamidoacetic acid (EtFOSAA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluorohexane sulfonic acid (PFHxS) were detected in >50% of women. These PFAS were not associated with risk of thyroid cancer, except for PFHxS, which was inversely associated (OR log2 = 0.82, 95% CI: 0.70‐0.97). We observed suggestive but imprecise increased risks associated with PFOA, PFOS, and EtFOSAA for those diagnosed at ages <40 years, whereas associations were null or inverse among those diagnosed at 40+ years (P‐interaction: .02, .08, .13, respectively). There was little evidence of other interactions. These results show no clear association between PFAS and papillary thyroid cancer risk. Future work would benefit from evaluation of these relationships among those with higher exposure levels and during periods of early development when the thyroid gland may be more susceptible to environmental harms.
What's new?
Per‐ and polyfluoroalkyl substances (PFAS) are endocrine disrupting chemicals that may increase thyroid cancer risk. Most PFAS studies of thyroid cancer were conducted in the United States and evaluated only perfluorooctanoic acid. Here, serum levels of 19 PFAS were measured in women in the Finnish Maternity Cohort to identify associations with thyroid cancer. Analyses reveal suggestive associations between PFAS and thyroid cancer risk for women under age 40 and no association or inverse associations for women over age 40. Further investigation is warranted to elucidate risks related to high PFAS exposure during early development.</description><identifier>ISSN: 0020-7136</identifier><identifier>ISSN: 1097-0215</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.34776</identifier><identifier>PMID: 37902275</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Acids ; Alkanesulfonic Acids ; Cancer ; Case-Control Studies ; Drinking water ; Environmental Pollutants ; Female ; Finland - epidemiology ; Fluorocarbons - adverse effects ; Food contamination ; Humans ; Medical research ; Papillary thyroid cancer ; Perfluorochemicals ; Perfluorodecanoic acid ; Perfluorohexane ; Perfluorooctane sulfonic acid ; Perfluorooctanoic acid ; persistent pollutants ; per‐ and polyfluoroalkyl substances ; PFAS ; PFOA ; PFOS ; Pregnancy ; Serum levels ; Sulfonic Acids ; Thyroid cancer ; Thyroid Cancer, Papillary - epidemiology ; Thyroid Neoplasms - epidemiology ; Thyroid Neoplasms - etiology</subject><ispartof>International journal of cancer, 2024-03, Vol.154 (6), p.979-991</ispartof><rights>2023 UICC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.</rights><rights>2024 UICC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-dd51f1f38c1433c691373a9c0c4445e5b5d69de1b865a8c84bf0529f94594bcb3</citedby><cites>FETCH-LOGICAL-c3536-dd51f1f38c1433c691373a9c0c4445e5b5d69de1b865a8c84bf0529f94594bcb3</cites><orcidid>0000-0001-5303-5109 ; 0000-0001-6416-4432 ; 0000-0003-2329-9933 ; 0000-0001-8825-5750 ; 0000-0003-1294-1679</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37902275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Madrigal, Jessica M.</creatorcontrib><creatorcontrib>Troisi, Rebecca</creatorcontrib><creatorcontrib>Surcel, Heljä‐Marja</creatorcontrib><creatorcontrib>Öhman, Hanna</creatorcontrib><creatorcontrib>Kivelä, Juha</creatorcontrib><creatorcontrib>Kiviranta, Hannu</creatorcontrib><creatorcontrib>Rantakokko, Panu</creatorcontrib><creatorcontrib>Koponen, Jani</creatorcontrib><creatorcontrib>Medgyesi, Danielle N.</creatorcontrib><creatorcontrib>Kitahara, Cari M.</creatorcontrib><creatorcontrib>McGlynn, Katherine A.</creatorcontrib><creatorcontrib>Sampson, Joshua</creatorcontrib><creatorcontrib>Albert, Paul S.</creatorcontrib><creatorcontrib>Ward, Mary H.</creatorcontrib><creatorcontrib>Jones, Rena R.</creatorcontrib><title>Prediagnostic serum concentrations of per‐ and polyfluoroalkyl substances and risk of papillary thyroid cancer in the Finnish Maternity Cohort</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Human exposure to per‐ and polyfluoroalkyl substances (PFAS) occurs globally through contaminated food, dust, and drinking water. Studies of PFAS and thyroid cancer have been limited. We conducted a nested case‐control study of prediagnostic serum levels of 19 PFAS and papillary thyroid cancer (400 cases, 400 controls) in the Finnish Maternity Cohort (pregnancies 1986‐2010; follow‐up through 2016), individually matched on sample year and age. We used conditional logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for log2 transformed and categorical exposures, overall and stratified by calendar period, birth cohort, and median age at diagnosis. We adjusted for other PFAS with Spearman correlation rho = 0.3‐0.6. Seven PFAS, including perfluoroctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), N‐ethyl‐perfluorooctane sulfonamidoacetic acid (EtFOSAA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluorohexane sulfonic acid (PFHxS) were detected in >50% of women. These PFAS were not associated with risk of thyroid cancer, except for PFHxS, which was inversely associated (OR log2 = 0.82, 95% CI: 0.70‐0.97). We observed suggestive but imprecise increased risks associated with PFOA, PFOS, and EtFOSAA for those diagnosed at ages <40 years, whereas associations were null or inverse among those diagnosed at 40+ years (P‐interaction: .02, .08, .13, respectively). There was little evidence of other interactions. These results show no clear association between PFAS and papillary thyroid cancer risk. Future work would benefit from evaluation of these relationships among those with higher exposure levels and during periods of early development when the thyroid gland may be more susceptible to environmental harms.
What's new?
Per‐ and polyfluoroalkyl substances (PFAS) are endocrine disrupting chemicals that may increase thyroid cancer risk. Most PFAS studies of thyroid cancer were conducted in the United States and evaluated only perfluorooctanoic acid. Here, serum levels of 19 PFAS were measured in women in the Finnish Maternity Cohort to identify associations with thyroid cancer. Analyses reveal suggestive associations between PFAS and thyroid cancer risk for women under age 40 and no association or inverse associations for women over age 40. Further investigation is warranted to elucidate risks related to high PFAS exposure during early development.</description><subject>Acids</subject><subject>Alkanesulfonic Acids</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Drinking water</subject><subject>Environmental Pollutants</subject><subject>Female</subject><subject>Finland - epidemiology</subject><subject>Fluorocarbons - adverse effects</subject><subject>Food contamination</subject><subject>Humans</subject><subject>Medical research</subject><subject>Papillary thyroid cancer</subject><subject>Perfluorochemicals</subject><subject>Perfluorodecanoic acid</subject><subject>Perfluorohexane</subject><subject>Perfluorooctane sulfonic acid</subject><subject>Perfluorooctanoic acid</subject><subject>persistent pollutants</subject><subject>per‐ and polyfluoroalkyl substances</subject><subject>PFAS</subject><subject>PFOA</subject><subject>PFOS</subject><subject>Pregnancy</subject><subject>Serum levels</subject><subject>Sulfonic Acids</subject><subject>Thyroid cancer</subject><subject>Thyroid Cancer, Papillary - epidemiology</subject><subject>Thyroid Neoplasms - epidemiology</subject><subject>Thyroid Neoplasms - etiology</subject><issn>0020-7136</issn><issn>1097-0215</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kc1u1DAUhS0EotPCghdAltjAIq2vf-J4iUYUilqVBawjx3EYTzN2sB2h7HiEPmOfpO5MywKJ1ZXu_c7R0T0IvQFyCoTQM7c1p4xLWT9DKyBKVoSCeI5W5UYqCaw-QscpbQkBEIS_REdMKkKpFCt0-y3a3umfPqTsDE42zjtsgjfW56izCz7hMODJxrs_t1j7Hk9hXIZxDjHo8WYZcZq7lHURpP05unSzV-jJjaOOC86bJQbXY_MARex82Vh87rx3aYOvdLbRu7zgddiEmF-hF4Mek339OE_Qj_NP39dfqsvrzxfrj5eVYYLVVd8LGGBgjQHOmKkVMMm0MsRwzoUVnehr1VvomlroxjS8G4igalBcKN6Zjp2g9wffKYZfs0253blkbInsbZhTS5uGQyNA0oK--wfdhjn6kq6lCiRQqKUs1IcDZWJIKdqhnaLblQe0QNqHmtpSU7uvqbBvHx3nbmf7v-RTLwU4OwC_3WiX_zu1F1_XB8t7SzmfQQ</recordid><startdate>20240315</startdate><enddate>20240315</enddate><creator>Madrigal, Jessica M.</creator><creator>Troisi, Rebecca</creator><creator>Surcel, Heljä‐Marja</creator><creator>Öhman, Hanna</creator><creator>Kivelä, Juha</creator><creator>Kiviranta, Hannu</creator><creator>Rantakokko, Panu</creator><creator>Koponen, Jani</creator><creator>Medgyesi, Danielle N.</creator><creator>Kitahara, Cari M.</creator><creator>McGlynn, Katherine A.</creator><creator>Sampson, Joshua</creator><creator>Albert, Paul S.</creator><creator>Ward, Mary H.</creator><creator>Jones, Rena R.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5303-5109</orcidid><orcidid>https://orcid.org/0000-0001-6416-4432</orcidid><orcidid>https://orcid.org/0000-0003-2329-9933</orcidid><orcidid>https://orcid.org/0000-0001-8825-5750</orcidid><orcidid>https://orcid.org/0000-0003-1294-1679</orcidid></search><sort><creationdate>20240315</creationdate><title>Prediagnostic serum concentrations of per‐ and polyfluoroalkyl substances and risk of papillary thyroid cancer in the Finnish Maternity Cohort</title><author>Madrigal, Jessica M. ; Troisi, Rebecca ; Surcel, Heljä‐Marja ; Öhman, Hanna ; Kivelä, Juha ; Kiviranta, Hannu ; Rantakokko, Panu ; Koponen, Jani ; Medgyesi, Danielle N. ; Kitahara, Cari M. ; McGlynn, Katherine A. ; Sampson, Joshua ; Albert, Paul S. ; Ward, Mary H. ; Jones, Rena R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-dd51f1f38c1433c691373a9c0c4445e5b5d69de1b865a8c84bf0529f94594bcb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acids</topic><topic>Alkanesulfonic Acids</topic><topic>Cancer</topic><topic>Case-Control Studies</topic><topic>Drinking water</topic><topic>Environmental Pollutants</topic><topic>Female</topic><topic>Finland - epidemiology</topic><topic>Fluorocarbons - adverse effects</topic><topic>Food contamination</topic><topic>Humans</topic><topic>Medical research</topic><topic>Papillary thyroid cancer</topic><topic>Perfluorochemicals</topic><topic>Perfluorodecanoic acid</topic><topic>Perfluorohexane</topic><topic>Perfluorooctane sulfonic acid</topic><topic>Perfluorooctanoic acid</topic><topic>persistent pollutants</topic><topic>per‐ and polyfluoroalkyl substances</topic><topic>PFAS</topic><topic>PFOA</topic><topic>PFOS</topic><topic>Pregnancy</topic><topic>Serum levels</topic><topic>Sulfonic Acids</topic><topic>Thyroid cancer</topic><topic>Thyroid Cancer, Papillary - epidemiology</topic><topic>Thyroid Neoplasms - epidemiology</topic><topic>Thyroid Neoplasms - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Madrigal, Jessica M.</creatorcontrib><creatorcontrib>Troisi, Rebecca</creatorcontrib><creatorcontrib>Surcel, Heljä‐Marja</creatorcontrib><creatorcontrib>Öhman, Hanna</creatorcontrib><creatorcontrib>Kivelä, Juha</creatorcontrib><creatorcontrib>Kiviranta, Hannu</creatorcontrib><creatorcontrib>Rantakokko, Panu</creatorcontrib><creatorcontrib>Koponen, Jani</creatorcontrib><creatorcontrib>Medgyesi, Danielle N.</creatorcontrib><creatorcontrib>Kitahara, Cari M.</creatorcontrib><creatorcontrib>McGlynn, Katherine A.</creatorcontrib><creatorcontrib>Sampson, Joshua</creatorcontrib><creatorcontrib>Albert, Paul S.</creatorcontrib><creatorcontrib>Ward, Mary H.</creatorcontrib><creatorcontrib>Jones, Rena R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Madrigal, Jessica M.</au><au>Troisi, Rebecca</au><au>Surcel, Heljä‐Marja</au><au>Öhman, Hanna</au><au>Kivelä, Juha</au><au>Kiviranta, Hannu</au><au>Rantakokko, Panu</au><au>Koponen, Jani</au><au>Medgyesi, Danielle N.</au><au>Kitahara, Cari M.</au><au>McGlynn, Katherine A.</au><au>Sampson, Joshua</au><au>Albert, Paul S.</au><au>Ward, Mary H.</au><au>Jones, Rena R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediagnostic serum concentrations of per‐ and polyfluoroalkyl substances and risk of papillary thyroid cancer in the Finnish Maternity Cohort</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2024-03-15</date><risdate>2024</risdate><volume>154</volume><issue>6</issue><spage>979</spage><epage>991</epage><pages>979-991</pages><issn>0020-7136</issn><issn>1097-0215</issn><eissn>1097-0215</eissn><abstract>Human exposure to per‐ and polyfluoroalkyl substances (PFAS) occurs globally through contaminated food, dust, and drinking water. Studies of PFAS and thyroid cancer have been limited. We conducted a nested case‐control study of prediagnostic serum levels of 19 PFAS and papillary thyroid cancer (400 cases, 400 controls) in the Finnish Maternity Cohort (pregnancies 1986‐2010; follow‐up through 2016), individually matched on sample year and age. We used conditional logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for log2 transformed and categorical exposures, overall and stratified by calendar period, birth cohort, and median age at diagnosis. We adjusted for other PFAS with Spearman correlation rho = 0.3‐0.6. Seven PFAS, including perfluoroctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), N‐ethyl‐perfluorooctane sulfonamidoacetic acid (EtFOSAA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluorohexane sulfonic acid (PFHxS) were detected in >50% of women. These PFAS were not associated with risk of thyroid cancer, except for PFHxS, which was inversely associated (OR log2 = 0.82, 95% CI: 0.70‐0.97). We observed suggestive but imprecise increased risks associated with PFOA, PFOS, and EtFOSAA for those diagnosed at ages <40 years, whereas associations were null or inverse among those diagnosed at 40+ years (P‐interaction: .02, .08, .13, respectively). There was little evidence of other interactions. These results show no clear association between PFAS and papillary thyroid cancer risk. Future work would benefit from evaluation of these relationships among those with higher exposure levels and during periods of early development when the thyroid gland may be more susceptible to environmental harms.
What's new?
Per‐ and polyfluoroalkyl substances (PFAS) are endocrine disrupting chemicals that may increase thyroid cancer risk. Most PFAS studies of thyroid cancer were conducted in the United States and evaluated only perfluorooctanoic acid. Here, serum levels of 19 PFAS were measured in women in the Finnish Maternity Cohort to identify associations with thyroid cancer. Analyses reveal suggestive associations between PFAS and thyroid cancer risk for women under age 40 and no association or inverse associations for women over age 40. Further investigation is warranted to elucidate risks related to high PFAS exposure during early development.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>37902275</pmid><doi>10.1002/ijc.34776</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-5303-5109</orcidid><orcidid>https://orcid.org/0000-0001-6416-4432</orcidid><orcidid>https://orcid.org/0000-0003-2329-9933</orcidid><orcidid>https://orcid.org/0000-0001-8825-5750</orcidid><orcidid>https://orcid.org/0000-0003-1294-1679</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-7136 |
| ispartof | International journal of cancer, 2024-03, Vol.154 (6), p.979-991 |
| issn | 0020-7136 1097-0215 1097-0215 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Acids Alkanesulfonic Acids Cancer Case-Control Studies Drinking water Environmental Pollutants Female Finland - epidemiology Fluorocarbons - adverse effects Food contamination Humans Medical research Papillary thyroid cancer Perfluorochemicals Perfluorodecanoic acid Perfluorohexane Perfluorooctane sulfonic acid Perfluorooctanoic acid persistent pollutants per‐ and polyfluoroalkyl substances PFAS PFOA PFOS Pregnancy Serum levels Sulfonic Acids Thyroid cancer Thyroid Cancer, Papillary - epidemiology Thyroid Neoplasms - epidemiology Thyroid Neoplasms - etiology |
| title | Prediagnostic serum concentrations of per‐ and polyfluoroalkyl substances and risk of papillary thyroid cancer in the Finnish Maternity Cohort |
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