Thermosensitive poly( N-isopropylacrylamide) nanocapsules with controlled permeability

In this paper, novel thermosensitive poly( N-isopropylacrylamide) (PNIPAM) nanocapsules with temperature-tunable diameter and permeability are reported. Firstly, the core-shell composite microparticles were synthesized by precipitation polymerization with isothiocyanate fluorescein (FITC) entrapped...

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Bibliographic Details
Published in:Polymer (Guildford) 2005-02, Vol.46 (4), p.1087-1093
Main Authors: Gao, Haifeng, Yang, Wuli, Min, Ke, Zha, Liusheng, Wang, Changchun, Fu, Shoukuan
Format: Article
Language:English
Subjects:
Applied sciences
Exact sciences and technology
Forms of application and semi-finished materials
Miscellaneous
Nanocapsules
Poly( N-isopropylacrylamide)
Polymer industry, paints, wood
Technology of polymers
Thermosensitive
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Summary:In this paper, novel thermosensitive poly( N-isopropylacrylamide) (PNIPAM) nanocapsules with temperature-tunable diameter and permeability are reported. Firstly, the core-shell composite microparticles were synthesized by precipitation polymerization with isothiocyanate fluorescein (FITC) entrapped SiO 2 as core and cross-linked PNIPAM as shell. Then, the SiO 2 core was etched by hydrofluoric acid at certain condition and the pre-trapped FITC molecules remained within the inner cavity. The FITC release profile and TEM studies clearly indicate that the release behavior of FITC could be controlled effectively by the external temperature. Above the LCST of PNIPAM (32 °C), the dehydrated PNIPAM shell inhibited the release of FITC from the internal cavity while below its LCST, the fluorophore could permeate the swollen shell easily.
ISSN:0032-3861
1873-2291
DOI:10.1016/j.polymer.2004.11.078