Gingival mesenchymal stem cell therapy, immune cells, and immunoinflammatory application

MSC-based therapeutic strategies have proven to be incredibly effective. Robust self-renewal, multilineage differentiation, and potential for tissue regeneration and disease treatments are all features of MSCs isolated from oral tissue. Human exfoliated deciduous teeth, dental follicles, dental pulp...

Full description

Saved in:
Bibliographic Details
Published in:Molecular biology reports 2023-12, Vol.50 (12), p.10461-10469
Main Authors: Tolouei, Amir Ebrahimpour, Oruji, Farshid, Tehrani, Sahar, Rezaei, Sara, Mozaffari, Asieh, Jahri, Mohammad, Nasiri, Kamyar
Format: Article
Language:English
Subjects:
Alveolar bone
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Bone marrow
Cell Differentiation - physiology
Cell self-renewal
Cell therapy
Cells, Cultured
Dental pulp
Dentistry
Follicles
Gingiva
Histology
Homeostasis
Humans
Immunomodulation
Inflammation
Inflammatory bowel disease
Life Sciences
Ligands
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
Molecular biology
Morphology
Regeneration
Review
Stem cells
Teeth
Tissue engineering
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:MSC-based therapeutic strategies have proven to be incredibly effective. Robust self-renewal, multilineage differentiation, and potential for tissue regeneration and disease treatments are all features of MSCs isolated from oral tissue. Human exfoliated deciduous teeth, dental follicles, dental pulp, apical papilla SCs, and alveolar bone are the primary sources of oral MSC production. The early immunoinflammatory response is the first stage of the healing process. Oral MSCs can interact with various cells, such as immune cells, revealing potential immunomodulatory regulators. They also have strong differentiation and regeneration potential. Therefore, a ground-breaking strategy would be to research novel immunomodulatory approaches for treating disease and tissue regeneration that depend on the immunomodulatory activities of oral MSCs during tissue regeneration.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-023-08826-2