Postpartum antihypertensive treatment: Is there a correlation to placental lesions?

• Published in: Archives of gynecology and obstetrics 2024-07, Vol.310 (1), p.453-459
• Main Authors: Fridman Kogan, Zviya, Nahum Fridland, Shir, Ganer Herman, Hadas, Miremberg, Hadas, Bustan, Mor, Schreiber, Letizia, Kovo, Michal
• Format: Article
• Language: English
• Subjects: Adult; Antihypertensive Agents - therapeutic use; Antihypertensives; Case-Control Studies; Cesarean Section - statistics & numerical data; Endocrinology; Female; Gestational Age; Gynecology; Human Genetics; Humans; Maternal-Fetal Medicine; Medicine; Medicine & Public Health; Obstetrics/Perinatology/Midwifery; Placenta - blood supply; Placenta - pathology; Postpartum Period; Pre-Eclampsia - drug therapy; Preeclampsia; Pregnancy; Premature Birth; Retrospective Studies; Risk Factors
• ISSN: 1432-0711; 0932-0067; 1432-0711
• DOI: 10.1007/s00404-023-07263-7

Objective We aimed to examine the association of clinical risk factors and placental lesions, in gestations complicated with preeclampsia, with the need for antihypertensive treatment in the early postpartum period. Methods The computerized files and placental reports of all singleton deliveries at 24.0–42.0 weeks complicated by preeclampsia were reviewed between January 2013 and October 2020. Obstetric characteristics and placental lesions were compared between patients who required antihypertensive treatment in the early postpartum period and those who did not (control group). Placentas were classified into maternal and fetal malperfusion lesions and inflammatory responses. Results As compared to controls (n = 200), the anti-hypertensive treatment group (n = 95) was characterized by increased rates of preterm birth, preeclampsia with severe features, and cesarean delivery (p