An analysis of placental chorionic villous and decidual basalis tissue immunoreactivity in patients after cesarean section due to a placenta accreta spectrum disorder and elective cesarean section followed by the depressed mood

• Published in: The journal of obstetrics and gynaecology research 2024-01, Vol.50 (1), p.55-64
• Main Authors: Dutsch‐Wicherek, Magdalena Maria, Bączkowska, Monika, Knafel, Anna, Sadowski, Piotr, Gałązka, Krystyna, Lew‐Starowicz, Michał
• Format: Article
• Language: English
• Subjects: abnormally invasive placentation; Antigens; B7‐H4; Cesarean section; Cytotoxicity; Decidua; Fetuses; Immune system; Immunological tolerance; Immunoreactivity; Mental depression; Mental disorders; Mood; Placenta; placenta accreta spectrum disorder; Postpartum; Postpartum depression; reproductive immunology; Statistical analysis
• ISSN: 1341-8076; 1447-0756
• DOI: 10.1111/jog.15821

An analysis of placental chorionic villous and decidual basalis tissue immunoreactivity in patients after cesarean section due to a placenta accreta spectrum disorder and elective cesarean section followed by a depressed mood. Research Background Over the past few years, interest in investigating immune dysfunction in patients with psychiatric disorders has increased. B7‐H4 is a molecule with immunosuppressive properties that seems to play a key role in establishing maternal tolerance against fetal antigens. The aim of this study was to compare the B7‐H4 immunoreactivity levels in patients after cesarean section. Methods Placental and decidual tissue samples were obtained from 49 women who delivered at Bielański Hospital in Warsaw between 2009 and 2015. Fifteen of the patients developed postpartum depression and 14 had a diagnosis of placenta accreta spectrum. The control group consisted of 20 healthy patients on whom cesarean section was performed due to breech presentation at term. Results The highest levels of B7‐H4 immunoreactivity were found in the placental chorionic villous and decidual basalis tissue samples of the patients who later developed postpartum depression, while the lowest levels were found in the samples of those patients with a placenta accreta spectrum disorder. The difference between the B7‐H4 immunoreactivity levels of these two groups was statistically significant. The B7‐H4 expression levels were statistically significantly higher in the women in the postpartum depression group than in the control group. Conclusion Postpartum depression follows a disturbance of the suppressive milieu responsible for rebalancing the maternal immune system after the initial cytotoxic activation during labor.