Relationship between Increased Plasma Levels of Legumain and Properties of Coronary Atherosclerotic Plaque

BACKGROUNDMany clinical studies have confirmed that legumain is closely related to atherosclerosis. Unfortunately, different conclusions have been reached, and analyses and studies on atherosclerotic plaque characteristics in patients with increased plasma levels of legumain are still lacking.OBJECT...

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Published in:Arquivos brasileiros de cardiologia 2023-01, Vol.120 (11), p.e20230395-e20230395
Main Authors: Deng, Yunpeng, Fan, Yudong, Wu, Di, Zhang, Zilong, Zhang, Miaomiao, Huang, Zhiping, Gao, Yuxia
Format: Article
Language:eng ; por
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Summary:BACKGROUNDMany clinical studies have confirmed that legumain is closely related to atherosclerosis. Unfortunately, different conclusions have been reached, and analyses and studies on atherosclerotic plaque characteristics in patients with increased plasma levels of legumain are still lacking.OBJECTIVESThis study aimed to investigate the correlation between legumain and coronary atherosclerotic plaque characteristics.METHODSA total of 81 patients with coronary atherosclerotic heart disease (CHD), including 43 patients with unstable angina (UA) and 38 patients with stable angina (SA), were screened by coronary angiography. Intravascular ultrasound (IVUS) was performed to evaluate the characteristics of coronary atherosclerotic plaques, and plasma legumain levels were also measured. Values of p < 0.05 were considered significant.RESULTSLegumain concentration was significantly higher in the two CHD subgroups than in the control group (all p
ISSN:1678-4170
DOI:10.36660/abc.20230395