Effect of Remifentanil on the Tpeak-Tend Interval During Electroconvulsive Therapy

Introduction QT interval dispersion, which reflects the regional heterogeneity of ventricular repolarization, increases during electroconvulsive therapy (ECT). Tpeak-Tend (TpTe) is considered a new marker of the transmural dispersion of ventricular repolarization (TDR). This study aimed to evaluate...

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Bibliographic Details
Published in:Advances in therapy 2024, Vol.41 (1), p.262-270
Main Authors: Eda, Kozue, Akutsu, Kazuya, Takasusuki, Toshifumi, Yamaguchi, Shigeki
Format: Article
Language:English
Subjects:
Cardiology
Electrocardiography - methods
Electroconvulsive Therapy - adverse effects
Endocrinology
Humans
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Original Research
Pharmacology/Toxicology
Remifentanil
Rheumatology
UMIN
UMIN000051958
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Summary:Introduction QT interval dispersion, which reflects the regional heterogeneity of ventricular repolarization, increases during electroconvulsive therapy (ECT). Tpeak-Tend (TpTe) is considered a new marker of the transmural dispersion of ventricular repolarization (TDR). This study aimed to evaluate the effect of remifentanil on TpTe during ECT. Methods Forty-two patients who were scheduled to undergo ECT with American Society of Anesthesiologists physical status I or II randomly received 0.1 μg/kg remifentanil (group R: n  = 21) or saline (group C: n  = 21). After the induction of general anesthesia, we measured the TpTe, TpTe/QT, TpTe/QTc, TpTe/RR, TpTe/√RR and TpTe/ 3 √RR every minute during ECT (QT: QT interval, QTc: corrected QT interval, RR: RR interval). Statistical analysis was performed using two-way analysis of variance (ANOVA). Results Immediately (T0) and 1 min (T1) after electrical stimulation, the RRs (group C: T0; 654.2 ± 145.9 ms, T1; 657.3 ± 114.8 ms, group R: T0; 849.6 ± 249.3 ms, T1; 885.4 ± 213.6 ms, p  
ISSN:0741-238X
1865-8652
1865-8652
DOI:10.1007/s12325-023-02713-9