N‑Site Regulation of Pyridyltriazole in CpIr(N̂N)(H2O) Complexes Achieving Catalytic FA Dehydrogenation

• Published in: Inorganic chemistry 2023-11, Vol.62 (45), p.18375-18383
• Main Authors: Ge, Shun, Gong, Lishan, Yi, Pingping, Mo, Xiufang, Liu, Chao, Yi, Xiao-Yi, He, Piao
• Format: Article
• Language: English
• ISSN: 0020-1669; 1520-510X
• DOI: 10.1021/acs.inorgchem.3c01649

A series of novel Cp*Ir complexes with nitrogen-rich N̂N bidentate ligands were developed for the catalytic dehydrogenation of formic acid in water under base-free conditions. These complexes were synthesized by using pyridyl 1,2,4-triazole, methylated species, or pyridyl 1,2,3-triazole as a N-site regulation ligand and were fully characterized. Complex 1-H 2 O bearing 1,2,4-triazole achieved a high turnover frequency of 14192 h–1 at 90 °C in 4 M FA aqueous solution. The terminal and bridged Ir–H intermediates of 1-H 2 O were successfully detected by 1H NMR and mass spectrometry measurements. Kinetic isotope effect experiments and density functional theory (DFT) calculations were performed; then a plausible mechanism was proposed involving the β-hydride elimination and formation of H2. Water-assisted H2 release was proven to be the rate-determining step of the reaction. The distribution of Mulliken charges on N atoms of triazole ligand internally revealed that the ortho site N2 of 1-H 2 O with a higher electron density was conducive to efficient proton transfer. Additionally, the advantage of water-assisted short-range bridge of 1,2,4-triazole moieties led to a higher catalytic activity of 1-H 2 O. This study demonstrated the effectiveness of nitrogen-rich ligands on FA dehydrogenation and revealed a good strategy for N site regulation in the development of new homogeneous catalysts.