α-Pyrone Derivatives from Calcarisporium arbuscula Discovered by Genome Mining

A highly reducing polyketide synthase (HRPKS) gene cluster from the genome of was identified through genome mining. Heterologous expression of this cluster led to the production of four new α-pyrone compounds, calcapyrones A ( ) and B ( ), along with their biosynthetic intermediates calcapyrones C (...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2023-11, Vol.86 (11), p.2496-2501
Main Authors: Dong, Jia-Yu, Tang, Man-Cheng, Liu, Ling
Format: Article
Language:English
Subjects:
Hypocreales
Pyrones
Spectrum Analysis
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Summary:A highly reducing polyketide synthase (HRPKS) gene cluster from the genome of was identified through genome mining. Heterologous expression of this cluster led to the production of four new α-pyrone compounds, calcapyrones A ( ) and B ( ), along with their biosynthetic intermediates calcapyrones C ( ) and D ( ). The structures of these compounds were elucidated on the basis of extensive spectroscopic experiments, and the absolute configurations of the 7,8-diol moieties in and were assigned using Snatzke's method. The biosynthetic pathway of and was established through and experiments.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.3c00685