Vitamin K3 promotes CCL5 expression to recruit preadipocytes deposition to skeletal muscle

Intramuscular fat (IMF), also known as ectopic fat deposits in skeletal muscle. Researches of IMF mainly focus on increasing the number and size of intramuscular adipocytes in situ. However, recent studies have shown that chemokines secreted by skeletal muscle recruit adipocytes to increase intramus...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical and biophysical research communications 2023-12, Vol.686, p.149162-149162, Article 149162
Main Authors: Yu, Wensai, Qiu, Shengda, Li, Menting, Yao, Yao, Zhao, Yuelei, Wei, Wei, Zhang, Lifan, Chen, Jie
Format: Article
Language:English
Subjects:
Adipocytes - metabolism
Animals
Ligands
Mice
Muscle, Skeletal - metabolism
Vitamin K 3
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Intramuscular fat (IMF), also known as ectopic fat deposits in skeletal muscle. Researches of IMF mainly focus on increasing the number and size of intramuscular adipocytes in situ. However, recent studies have shown that chemokines secreted by skeletal muscle recruit adipocytes to increase intramuscular fat content. Chemokine ligand 5 (CCL5), a member of chemokine family, is involved in the regulation of cell migration, inflammatory responses, and energy metabolism. In this study, we determined Vitamin K3 (VK3) enhanced Ccl5 transcription and expression, thus resulting in increased preadipocyte migration. VK3-injected vastus lateralis (VL) was observed an increased CCL5 concentration and IMF deposition, whereas blockade of the CCL5/CCR5 axis decreased IMF deposition.VK3 treatment also increased the body weight and VL ratio in mice. In summary, VK3, which targets CCL5, is expected to be a novel pharmacological regulator for promoting IMF content.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2023.149162