Dose–Response Association of Benzodiazepine Use and Development of Deep Vein Thrombosis

•Benzodiazepines have sedative effects that cause reduced activity in users and may increase the risk of deep vein thrombosis.•Benzodiazepine prescription was associated with deep vein thrombosis occurrence.•The ORs of deep vein thrombosis occurrence increased with higher defined daily dose (DDD)/da...

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Bibliographic Details
Published in:Psychiatry research 2023-12, Vol.330, p.115553-115553, Article 115553
Main Authors: Shih, Nai-Chen, Yeh, Liang-Tsai, Wang, Bo-Yuan, Wang, Yu-Hsun, Yang, Shun-Fa, Yeh, Chao-Bin
Format: Article
Language:English
Subjects:
Benzodiazepines
deep vein thrombosis
nested case-control study
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Summary:•Benzodiazepines have sedative effects that cause reduced activity in users and may increase the risk of deep vein thrombosis.•Benzodiazepine prescription was associated with deep vein thrombosis occurrence.•The ORs of deep vein thrombosis occurrence increased with higher defined daily dose (DDD)/day.•Evaluating the benefits and risks of benzodiazepine prescription is critical. Benzodiazepines have sedative effects that cause reduced activity in users and may increase the risk of deep vein thrombosis. However, few studies have examined this potential risk of benzodiazepine use. This study examined the association between benzodiazepine use and the risk of deep vein thrombosis (DVT) in adults in Taiwan using a longitudinal health insurance database. The study population included 12,546 individuals with DVT and 50,184 matched controls. Results showed that benzodiazepine use was associated with an increased risk of DVT occurrence (adjusted odds ratio [aOR]: 1.66; 95% CI, 1.54–1.79; P
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2023.115553