Blood-brain barrier permeability in the ischemic stroke: An update

Stroke is the second leading cause of death globally and the major cause of long-term disability. Among the types of strokes, ischemic stroke, which occurs due to obstruction of blood vessels responsible for cerebral irrigation, is considered the most prevalent, accounting for approximately 86 % of...

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Bibliographic Details
Published in:Microvascular research 2024-01, Vol.151, p.104621-104621, Article 104621
Main Authors: Mathias, Khiany, Machado, Richard Simon, Stork, Solange, Dos Santos, David, Joaquim, Larissa, Generoso, Jaqueline, Danielski, Lucinéia Gainski, Barichello, Tatiana, Prophiro, Josiane Somariva, Petronilho, Fabricia
Format: Article
Language:English
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Summary:Stroke is the second leading cause of death globally and the major cause of long-term disability. Among the types of strokes, ischemic stroke, which occurs due to obstruction of blood vessels responsible for cerebral irrigation, is considered the most prevalent, accounting for approximately 86 % of all stroke cases. This interruption of blood supply leads to a critical pathophysiological mechanism, including oxidative stress and neuroinflammation which are responsible for structural alterations of the blood-brain barrier (BBB). The increased BBB permeability associated with cerebral ischemia-reperfusion may contribute to a worse outcome after stroke. Thus, this narrative review aims to update the pathophysiological mechanisms involved in the increase in BBB permeability and to list the possible therapeutic strategies.
ISSN:0026-2862
1095-9319
DOI:10.1016/j.mvr.2023.104621