Antitumor effect of exopolysaccharide from Lactiplantibacillus plantarum WLPL09 on melanoma mice via regulating immunity and gut microbiota

Exopolysaccharide (EPS-09) from L. plantarum WLPL09 was systemically investigated for the antitumor effect in B16F10 melanoma bearing mice model. The results showed that administraion of EPS-09 (200 mg/kg) could sigificantly inhibit the tumor growth of melanoma bearing mice, with a inhibition rate o...

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Bibliographic Details
Published in:International journal of biological macromolecules 2024-01, Vol.254 (Pt 1), p.127624-127624, Article 127624
Main Authors: Wang, Qi'an, Jiang, Bensheng, Wei, Min, He, Yao, Wang, Yujie, Zhang, Qimeng, Wei, Hua, Tao, Xueying
Format: Article
Language:English
Subjects:
angiogenesis
antineoplastic activity
Antitumor activity
apoptosis
blood serum
caspase-3
caspase-9
Exopolysaccharide
exopolysaccharides
family
genus
Gut microbiota
Immunity
interleukin-2
interleukin-6
intestinal microorganisms
Lachnospiraceae
Lactiplantibacillus plantarum
Melanoma
neoplasm cells
Oscillospira
Prevotella
Ruminococcus
spleen
transcription (genetics)
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Summary:Exopolysaccharide (EPS-09) from L. plantarum WLPL09 was systemically investigated for the antitumor effect in B16F10 melanoma bearing mice model. The results showed that administraion of EPS-09 (200 mg/kg) could sigificantly inhibit the tumor growth of melanoma bearing mice, with a inhibition rate of 42.53 %. Meanwhile, compared to the Model group, high dose of EPS-09 (200 mg/kg) administraion could increase the spleen index (P = 0.10), promote the splenic lymphocytes proliferation under the stimulation of ConA and LPS with a proliferation rate of 120.58 % and 169.88 %, respectively, enhance the amount of CD4+ and CD8+ T cells (P 
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2023.127624