Genome-driven discovery of new serrawettin W2 analogues from Serratia fonticola DSM 4576

By expressing a multimodular NRPS gene sefA from Serratia fonticola DSM 4576 in E. coli , four new serrawettin W2 analogues, namely sefopeptides A–D (1–4), were isolated and structurally characterized and their biosynthesis was proposed. A bioactivity assay showed that sefopeptide C (3) exhibits mod...

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Published in:Organic & biomolecular chemistry 2023-11, Vol.21 (45), p.9029-9036
Main Authors: Qiu, Haolin, Xiao, Yang, Shen, Ling, Han, Tao, He, Qiang, Li, Aiying, Zhang, Peng, Cai, Xiaofeng
Format: Article
Language:English
Subjects:
Acute promyeloid leukemia
Bacteria
Biological activity
Biosynthesis
Cytotoxicity
E coli
Genomes
Leukemia
NRPS gene
Promyeloid leukemia
Serratia fonticola
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Summary:By expressing a multimodular NRPS gene sefA from Serratia fonticola DSM 4576 in E. coli , four new serrawettin W2 analogues, namely sefopeptides A–D (1–4), were isolated and structurally characterized and their biosynthesis was proposed. A bioactivity assay showed that sefopeptide C (3) exhibits moderate cytotoxic activity against acute promyelocytic leukemia NB4 cells.
ISSN:1477-0520
1477-0539
DOI:10.1039/d3ob01642k