Treatment of rheumatoid arthritis with curcumin analog 3,5-bis(arylidene)-4-piperidone

Rheumatoid arthritis (RA) is an inflammatory disease. Curcumin can inhibit NF-κB and reduce the expression of inflammation-related genes. To evaluate the potential development of in the clinical treatment of inflammatory diseases such as RA. Using a skeleton fusion strategy to synthesize curcumin an...

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Bibliographic Details
Published in:Future medicinal chemistry 2023-11, Vol.15 (22), p.2051-2064
Main Authors: Li, Wenxuan, Yan, Weibin, Liu, Yongjun, Hou, Guige, Li, Chengbo
Format: Article
Language:English
Subjects:
3,5-Bis(arylidene)-4-piperidone derivatives
Animals
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - metabolism
BAPs
Curcumin - pharmacology
Curcumin - therapeutic use
Inflammation
MAPK
Molecular Docking Simulation
NF-kappa B
NF-κB
Piperidones - pharmacology
Piperidones - therapeutic use
Rats
rheumatoid arthritis
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Description
Summary:Rheumatoid arthritis (RA) is an inflammatory disease. Curcumin can inhibit NF-κB and reduce the expression of inflammation-related genes. To evaluate the potential development of in the clinical treatment of inflammatory diseases such as RA. Using a skeleton fusion strategy to synthesize curcumin analogues for . This work evaluates anti-inflammatory activity by conducting anti-arthritis experiments (adjuvant-induced RA models) on rats. Western blot and Elisa were used to detect the expression of inflammatory-related proteins and cytokines. Molecular docking analysis confirmed the binding effect of with active sites. inhibits NF-κB has a protective effect on arthritis caused by RA.
ISSN:1756-8919
1756-8927
DOI:10.4155/fmc-2023-0119