Finite element analysis of zonular forces

• Published in: Experimental eye research 2023-12, Vol.237, p.109709-109709, Article 109709
• Main Authors: Schachar, Ronald A, Schachar, Ira H, Pu, Yutian, Kumar, Shubham, Cosman, Pamela C, Pierscionek, Barbara K, Wang, Kehao
• Format: Article
• Language: English
• Subjects: Ciliary Body; Finite Element Analysis; Lens Capsule, Crystalline - physiology; Lens, Crystalline - physiology; Muscle, Smooth
• ISSN: 0014-4835; 1096-0007
• DOI: 10.1016/j.exer.2023.109709

To determine the effect of zonular forces on lens capsule topography, a finite element (FE) analyses of lens capsules with no lens stroma and constant and variable thickness with anterior capsulotomies of 1.5 mm-6.5 mm were evaluated when subjected to equatorial (Ez), anterior (Az) and posterior (Pz) zonular forces. The lens capsule was considered in the unaccommodated state when the total initial zonular force was 0.00075 N or 0.3 N. From the total 0.00075 N zonular force, the Ez force was increased in 0.000125 N steps for a maximum force of 0.03 N and simultaneously the Az plus Pz force was reduced in 0.000125 N steps to zero. In addition, the force of all the zonules was reduced from 0.00075 N and separately from 0.3 N in 0.000125 N steps to zero. Only when Ez force was increased as Az and Pz force was reduced did the capsule topography simulate in vivo observations with the posterior capsule pole bowing posteriorly. The posterior bowing was directly related to Ez force and capsulotomy size. Whether the total force of all the zonules in the unaccommodated state was 0.00075 N or 0.3 N and reduced in steps to zero, the lens capsule topography did not emulate the in vivo observations. The FE analysis demonstrated that Ez tension increases while the Az and Pz tension decreases and that all the zonules do not relax during ciliary muscle contraction.