Indirect impact of the COVID-19 pandemic on the care and outcomes of people with MS: A combined survey and insurance claims study

• Published in: Multiple sclerosis and related disorders 2023-12, Vol.80, p.105085-105085, Article 105085
• Main Authors: Meltzer, Ethan, Charron, Odelin, Wozny, Joe, Onuorah, Helen, Montague, Amanda, Kline, Alexis Crispino, Largent, Avery, Krause, Trudy Millard, Freeman, Leorah
• Format: Article
• Language: English
• Subjects: Administrative claims; Aged; Anxiety; COVID-19; Disease modifying therapy; Healthcare resource utilization; Humans; Insurance; Multiple sclerosis; Multiple Sclerosis - epidemiology; Multiple Sclerosis - therapy; Pandemics; Retrospective Studies
• ISSN: 2211-0348; 2211-0356
• DOI: 10.1016/j.msard.2023.105085

•Over 47 % of pwMS reported neurological worsening during the COVID-19 pandemic.•Despite the expansion of telemedicine, access to healthcare services decreased.•DMT utilization shifted during the pandemic, particularly for those older than 55.•Fewer pwMS underwent MRI monitoring during the first year of the pandemic. In the context of the COVID-19 pandemic, people with multiple sclerosis (pwMS) have been particularly vulnerable to adverse outcomes due to increased risk of severe infection and/or widespread disruptions in care. The CopeMS study led by The University of Texas at Austin and the MS Association of America investigates the long-term impact of the COVID-19 pandemic on healthcare access, disease modifying therapy (DMT) utilization and outcomes of pwMS. This retrospective cohort analysis used Optum's de-identified Clinformatics® Data Mart Database (CDM), a large de-identified administrative healthcare claims database to identify pwMS who were continuously enrolled from 01/01/2019 to 12/31/2020 and assessed changes in the utilization of DMTs and healthcare services during the COVID-19 pandemic compared to the year prior. Additionally, a national survey of pwMS and healthcare providers (HCPs) was conducted to further understand the indirect impact of the pandemic on healthcare resource utilization (HCRU), outcomes and prescription patterns. Out of 529 pwMS in our national survey, over 47 % reported that their overall health and neurologic symptoms had deteriorated during the COVID-19 pandemic, with increased anxiety, and inability to maintain exercise habits as leading perceived causes for worsening. Survey respondents reported widespread disruption of MS-related services during the pandemic. In the Optum database, we identified 39,209 pwMS validating inclusion criteria. We observed a decrease in the utilization of MS-related services in 2020 compared to 2019. Significantly fewer pwMS had visits with their neurologist, primary care provider, physical or occupational therapist despite an increased utilization of telemedicine services. Fewer pwMS had magnetic resonance imaging (MRI) studies of the brain or spinal cord during the pandemic. Only 22.2 % of HCPs surveyed agreed that the perceived risk of more severe COVID-19 infection on a specific DMT influenced their therapeutic decisions. In the Optum database, individuals with an established diagnosis of MS prior to 2019 saw decreases in utilization of platform and moderate efficacy DMTs. In this group